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Psma2 proteasome subunit alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 19166, updated on 1-Mar-2024

Summary

Official Symbol
Psma2provided by MGI
Official Full Name
proteasome subunit alpha 2provided by MGI
Primary source
MGI:MGI:104885
See related
Ensembl:ENSMUSG00000015671 AllianceGenome:MGI:104885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmpc3
Summary
Predicted to be involved in proteasomal protein catabolic process. Located in P-body. Part of proteasome core complex. Orthologous to human PSMA2 (proteasome 20S subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 107.2), liver E14 (RPKM 90.2) and 28 other tissues See more
Orthologs
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Genomic context

See Psma2 in Genome Data Viewer
Location:
13 A1; 13 5.36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (14787827..14800258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (14613242..14625673)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32526 Neighboring gene STARR-positive B cell enhancer ABC_E5370 Neighboring gene mitochondrial ribosomal protein L32 Neighboring gene expressed sequence AW209491 Neighboring gene STARR-seq mESC enhancer starr_33717 Neighboring gene STARR-seq mESC enhancer starr_33718 Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-2
Names
macropain subunit C3
multicatalytic endopeptidase complex subunit C3
proteasome (prosome, macropain) subunit, alpha type 2
proteasome component C3
NP_032970.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008944.2NP_032970.2  proteasome subunit alpha type-2

    See identical proteins and their annotated locations for NP_032970.2

    Status: VALIDATED

    Source sequence(s)
    AK152862, BU755659, CJ052982
    Consensus CDS
    CCDS36602.1
    UniProtKB/Swiss-Prot
    E9Q3A4, P49722, Q6ZWV8
    UniProtKB/TrEMBL
    Q9CZ58
    Related
    ENSMUSP00000129767.3, ENSMUST00000170836.4
    Conserved Domains (1) summary
    cd03750
    Location:6231
    proteasome_alpha_type_2; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    14787827..14800258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)