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Pros1 protein S (alpha) [ Mus musculus (house mouse) ]

Gene ID: 19128, updated on 12-May-2024

Summary

Official Symbol
Pros1provided by MGI
Official Full Name
protein S (alpha)provided by MGI
Primary source
MGI:MGI:1095733
See related
Ensembl:ENSMUSG00000022912 AllianceGenome:MGI:1095733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 16.0), bladder adult (RPKM 11.9) and 27 other tissues See more
Orthologs
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Genomic context

See Pros1 in Genome Data Viewer
Location:
16 C1.3; 16 36.43 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (62674670..62749709)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (62854307..62929346)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41128 Neighboring gene NOL1/NOP2/Sun domain family member 3 Neighboring gene predicted gene, 52231 Neighboring gene STARR-positive B cell enhancer ABC_E7471 Neighboring gene ADP-ribosylation factor-like 13B Neighboring gene syntaxin 19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:62846895-62847078 Neighboring gene STARR-seq mESC enhancer starr_41130 Neighboring gene STARR-seq mESC enhancer starr_41131 Neighboring gene STARR-positive B cell enhancer mm9_chr16:62940376-62940676 Neighboring gene STARR-seq mESC enhancer starr_41132 Neighboring gene predicted gene, 53931 Neighboring gene zinc finger and SCAN domain containing 5B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vitamin K-dependent protein S

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011173.3NP_035303.1  vitamin K-dependent protein S preproprotein

    See identical proteins and their annotated locations for NP_035303.1

    Status: REVIEWED

    Source sequence(s)
    AK145501, AK163032, BE949628
    Consensus CDS
    CCDS28263.1
    UniProtKB/Swiss-Prot
    P43483, Q08761
    UniProtKB/TrEMBL
    Q3TR66
    Related
    ENSMUSP00000023629.9, ENSMUST00000023629.9
    Conserved Domains (6) summary
    smart00069
    Location:2385
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam00054
    Location:329459
    Laminin_G_1; Laminin G domain
    pfam06247
    Location:134287
    Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
    pfam07645
    Location:201241
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:165199
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl22861
    Location:514646
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    62674670..62749709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245843.4XP_011244145.1  vitamin K-dependent protein S isoform X1

    Conserved Domains (5) summary
    pfam07645
    Location:121161
    EGF_CA; Calcium-binding EGF domain
    pfam00008
    Location:4173
    EGF; EGF-like domain
    pfam00054
    Location:249379
    Laminin_G_1; Laminin G domain
    pfam14670
    Location:85119
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl22861
    Location:429566
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...