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Prop1 paired like homeodomain factor 1 [ Mus musculus (house mouse) ]

Gene ID: 19127, updated on 12-May-2024

Summary

Official Symbol
Prop1provided by MGI
Official Full Name
paired like homeodomain factor 1provided by MGI
Primary source
MGI:MGI:109330
See related
Ensembl:ENSMUSG00000044542 AllianceGenome:MGI:109330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
df; Prop-1
Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; beta-catenin binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; diencephalon development; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Prop1 in Genome Data Viewer
Location:
11 B1.3; 11 30.95 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50841633..50844584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50950806..50953757, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 354B Neighboring gene RIKEN cDNA 4933414I15 gene Neighboring gene olfactory receptor family 1 subfamily AD member 7, pseudogene 1 Neighboring gene olfactory receptor family 1 subfamily AD member 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hypophysis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hypothalamus cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within somatotropin secreting cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein prophet of Pit-1
Names
Ames dwarf
pituitary specific homeodomain factor
prophet of Pit-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008936.2NP_032962.1  homeobox protein prophet of Pit-1

    See identical proteins and their annotated locations for NP_032962.1

    Status: VALIDATED

    Source sequence(s)
    CJ165772, U77946
    Consensus CDS
    CCDS24643.1
    UniProtKB/Swiss-Prot
    P97458, Q5NCG9
    UniProtKB/TrEMBL
    Q8CJ18
    Related
    ENSMUSP00000057231.2, ENSMUST00000051159.3
    Conserved Domains (1) summary
    pfam00046
    Location:69122
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50841633..50844584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)