Format

Send to:

Choose Destination

Prnp prion protein [ Mus musculus (house mouse) ]

Gene ID: 19122, updated on 19-Oct-2021

Summary

Official Symbol
Prnpprovided by MGI
Official Full Name
prion proteinprovided by MGI
Primary source
MGI:MGI:97769
See related
Ensembl:ENSMUSG00000079037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP<C>; AA960666; AI325101; prP27-30; prP33-35C
Expression
Broad expression in cortex adult (RPKM 102.3), frontal lobe adult (RPKM 102.0) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prnp in Genome Data Viewer
Location:
2 F2; 2 64.07 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131751848..131780356)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131909928..131938436)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131735664..131764167)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endogenous retroviral sequence 3 Neighboring gene laminin receptor 1 (ribosomal protein SA), pseudogene 1 Neighboring gene prion protein readthrough transcript Neighboring gene prion like protein doppel Neighboring gene Ras association (RalGDS/AF-6) domain family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough Prn

Readthrough gene: Prn, Included gene: Prnd

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
enables aspartic-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cupric ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cuprous ion binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lamin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables type 5 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 5 metabotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in amyloid precursor protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium-mediated signaling using intracellular calcium source IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular copper ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to copper ion ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in learning or memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of age-related behavioral decline IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid precursor protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of amyloid-beta formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion import across plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of glutamate receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of intracellular calcium activated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peptidyl-tyrosine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to copper ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with dendrite IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane raft TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278256.1NP_001265185.1  major prion protein precursor

    See identical proteins and their annotated locations for NP_001265185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK158908, AK159056, AV361844, CK622972
    Consensus CDS
    CCDS16766.1
    UniProtKB/Swiss-Prot
    P04925
    UniProtKB/TrEMBL
    Q4FJQ7
    Conserved Domains (2) summary
    smart00157
    Location:23241
    PRP; Major prion protein
    pfam11587
    Location:128
    Prion_bPrPp; Major prion protein bPrPp - N terminal
  2. NM_011170.3NP_035300.1  major prion protein precursor

    See identical proteins and their annotated locations for NP_035300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK148061, AK158908, AV361844, CK622972
    Consensus CDS
    CCDS16766.1
    UniProtKB/Swiss-Prot
    P04925
    UniProtKB/TrEMBL
    Q3UG89, Q4FJQ7
    Related
    ENSMUSP00000088833.7, ENSMUST00000091288.13
    Conserved Domains (2) summary
    smart00157
    Location:23241
    PRP; Major prion protein
    pfam11587
    Location:128
    Prion_bPrPp; Major prion protein bPrPp - N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131751848..131780356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center