U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prm2 protamine 2 [ Mus musculus (house mouse) ]

Gene ID: 19119, updated on 1-Mar-2024

Summary

Official Symbol
Prm2provided by MGI
Official Full Name
protamine 2provided by MGI
Primary source
MGI:MGI:97766
See related
Ensembl:ENSMUSG00000038015 AllianceGenome:MGI:97766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prm-2
Summary
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is synthesized as a precursor and then cleaved to give rise to a family of protamine 2 peptides. [provided by RefSeq, Sep 2015]
Expression
Restricted expression toward testis adult (RPKM 5910.5) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prm2 in Genome Data Viewer
Location:
16 A1; 16 5.84 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10609241..10609969, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10791377..10792105, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transition protein 2 Neighboring gene protamine 3 Neighboring gene protamine 1 Neighboring gene STARR-seq mESC enhancer starr_40096 Neighboring gene 60S ribosomal protein L30-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome condensation TAS
Traceable Author Statement
more info
PubMed 
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleus organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
NOT located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protamine-2
Names
sperm histone P2
sperm protamine P2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008933.2NP_032959.1  protamine-2

    See identical proteins and their annotated locations for NP_032959.1

    Status: REVIEWED

    Source sequence(s)
    AK005729, AV207640
    Consensus CDS
    CCDS27955.1
    UniProtKB/Swiss-Prot
    P07978
    UniProtKB/TrEMBL
    C3U1R6, C3U1R7, C3U1R8, C3U1S0, Q545M0
    Related
    ENSMUSP00000047925.6, ENSMUST00000037996.7
    Conserved Domains (1) summary
    pfam00841
    Location:165
    Protamine_P2; Sperm histone P2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10609241..10609969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)