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Prim2 DNA primase, p58 subunit [ Mus musculus (house mouse) ]

Gene ID: 19076, updated on 2-Nov-2024

Summary

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Official Symbol
Prim2provided by MGI
Official Full Name
DNA primase, p58 subunitprovided by MGI
Primary source
MGI:MGI:97758
See related
Ensembl:ENSMUSG00000026134 AllianceGenome:MGI:97758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and DNA/RNA hybrid binding activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 13.3), liver E14.5 (RPKM 11.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Prim2 in Genome Data Viewer
Location:
1 12.7 cM; 1 B
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33492889..33708867, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33453808..33669808, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PRP3 pre-mRNA processing factor 3 homolog pseudogene Neighboring gene predicted gene, 23453 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:33635449-33635558 Neighboring gene STARR-seq mESC enhancer starr_00539 Neighboring gene STARR-positive B cell enhancer mm9_chr1:33719891-33720191 Neighboring gene RIKEN cDNA 1700001G17 gene Neighboring gene STARR-positive B cell enhancer mm9_chr1:33726515-33726816 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene predicted gene, 32229

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E2F regulates growth-dependent transcription of genes encoding both catalytic and regulatory subunits of mouse primase. Nishikawa N, et al. Genes Cells, 2001 Jan. PMID 11168597
  2. Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit. Mizuno T, et al. J Cell Sci, 1996 Nov. PMID 8937981
  3. Mouse primase p49 subunit molecular cloning indicates conserved and divergent regions. Prussak CE, et al. J Biol Chem, 1989 Mar 25. PMID 2925677
  4. Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Adler DA, et al. Genomics, 1991 Apr. PMID 2037291
  5. Molecular architecture of the mouse DNA polymerase alpha-primase complex. Mizuno T, et al. Mol Cell Biol, 1999 Nov. PMID 10523676, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables 4 iron, 4 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA/RNA hybrid binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA/RNA hybrid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication, synthesis of primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication, synthesis of primer ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA primase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA primase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of alpha DNA polymerase:primase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of alpha DNA polymerase:primase complex ISO
Inferred from Sequence Orthology
more info
  
part_of primosome complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA primase large subunit
Names
DNA primase 58 kDa subunit
NP_001407370.1
NP_001407371.1
NP_001407372.1
NP_001407373.1
NP_001407374.1
NP_001407375.1
NP_001407376.1
NP_001407378.1
NP_001407379.1
NP_001407380.1
NP_032948.1
XP_006495856.1
XP_006495860.1
XP_011236757.1
XP_030108155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420441.1 → NP_001407370.1  DNA primase large subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  2. NM_001420442.1 → NP_001407371.1  DNA primase large subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  3. NM_001420443.1 → NP_001407372.1  DNA primase large subunit isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  4. NM_001420444.1 → NP_001407373.1  DNA primase large subunit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  5. NM_001420445.1 → NP_001407374.1  DNA primase large subunit isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  6. NM_001420446.1 → NP_001407375.1  DNA primase large subunit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  7. NM_001420447.1 → NP_001407376.1  DNA primase large subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  8. NM_001420449.1 → NP_001407378.1  DNA primase large subunit isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  9. NM_001420450.1 → NP_001407379.1  DNA primase large subunit isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  10. NM_001420451.1 → NP_001407380.1  DNA primase large subunit isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435

  11. NM_008922.3 → NP_032948.1  DNA primase large subunit isoform 1

    See identical proteins and their annotated locations for NP_032948.1

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    Consensus CDS
    CCDS14862.1
    UniProtKB/Swiss-Prot
    P33610, Q3U4Z3
    UniProtKB/TrEMBL
    Q3THK0
    Related
    ENSMUSP00000027312.10, ENSMUST00000027312.11
    Conserved Domains (1) summary
    cd07322
    Location:28 → 451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

RNA

  1. NR_185176.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134435

  2. NR_185177.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134435

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    33492889..33708867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238455.3 → XP_011236757.1  DNA primase large subunit isoform X2

    Conserved Domains (1) summary
    cd07322
    Location:16 → 236
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  2. XM_030252295.2 → XP_030108155.1  DNA primase large subunit isoform X3

    Conserved Domains (1) summary
    cl11970
    Location:28 → 235
    PriL; Archaeal/eukaryotic core primase: Large subunit, PriL

  3. XM_006495793.5 → XP_006495856.1  DNA primase large subunit isoform X1

    Conserved Domains (1) summary
    cl11970
    Location:28 → 234
    PriL; Archaeal/eukaryotic core primase: Large subunit, PriL

  4. XM_006495797.4 → XP_006495860.1  DNA primase large subunit isoform X4

    Conserved Domains (1) summary
    cl11970
    Location:28 → 231
    PriL; Archaeal/eukaryotic core primase: Large subunit, PriL
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33610.1 GenPept UniProtKB/Swiss-Prot:P33610

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