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Ppib peptidylprolyl isomerase B [ Mus musculus (house mouse) ]

Gene ID: 19035, updated on 26-Sep-2022

Summary

Official Symbol
Ppibprovided by MGI
Official Full Name
peptidylprolyl isomerase Bprovided by MGI
Primary source
MGI:MGI:97750
See related
Ensembl:ENSMUSG00000032383 AllianceGenome:MGI:97750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cphn2; Cphn-2; CyP-20b
Summary
Predicted to enable RNA polymerase binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including neutrophil chemotaxis; positive regulation by host of viral genome replication; and protein stabilization. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including axial skeleton; cranium; otic capsule; and pancreas tip epithelium. Used to study osteogenesis imperfecta type 9. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 9. Orthologous to human PPIB (peptidylprolyl isomerase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 354.3), liver E18 (RPKM 213.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ppib in Genome Data Viewer
Location:
9; 9 C
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65967451..65973911)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66060169..66066629)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene PCNA clamp associated factor Neighboring gene predicted gene, 23248 Neighboring gene casein kinase 1, gamma 1 Neighboring gene predicted gene, 22657 Neighboring gene sorting nexin 22 Neighboring gene sorting nexin 1 Neighboring gene cytosolic iron-sulfur assembly component 2A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in bone development ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
part_of endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase B
Names
CYP-S1
PPIase B
S-cyclophilin
SCYLP
cyclophilin B
rotamase B
NP_035279.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011149.2NP_035279.2  peptidyl-prolyl cis-trans isomerase B precursor

    See identical proteins and their annotated locations for NP_035279.2

    Status: VALIDATED

    Source sequence(s)
    AK002357, AL363449, CA321924
    Consensus CDS
    CCDS23301.1
    UniProtKB/Swiss-Prot
    P24369
    UniProtKB/TrEMBL
    Q9DCY1
    Related
    ENSMUSP00000034947.6, ENSMUST00000034947.7
    Conserved Domains (1) summary
    cd01926
    Location:45203
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65967451..65973911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)