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Pou4f1 POU domain, class 4, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18996, updated on 8-Feb-2024

Summary

Official Symbol
Pou4f1provided by MGI
Official Full Name
POU domain, class 4, transcription factor 1provided by MGI
Primary source
MGI:MGI:102525
See related
Ensembl:ENSMUSG00000048349 AllianceGenome:MGI:102525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brn3; Brn-3; Brn3a; Brn3.0; Brn-3.0; E130119J07Rik
Summary
Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and GTPase binding activity. Involved in several processes, including cellular response to estradiol stimulus; nervous system development; and regulation of gene expression. Acts upstream of or within several processes, including nervous system development; proprioception involved in equilibrioception; and suckling behavior. Located in several cellular components, including chromatin; neuron projection; and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch mesenchyme; central nervous system; future brain; ganglia; and retina. Orthologous to human POU4F1 (POU class 4 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 5.1), CNS E14 (RPKM 4.6) and 3 other tissues See more
Orthologs
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Genomic context

See Pou4f1 in Genome Data Viewer
Location:
14 E2.3; 14 54.21 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (104699111..104705554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (104461675..104468118, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52151 Neighboring gene RIKEN cDNA D130079A08 gene Neighboring gene predicted gene, 35362 Neighboring gene ORC ubiquitin ligase 1 Neighboring gene predicted gene, 22021

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration in hindbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within habenula development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peripheral nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proprioception involved in equilibrioception IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_negative_effect regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sensory system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within suckling behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trigeminal nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular compact myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
POU domain, class 4, transcription factor 1
Names
brain-3A
brain-specific homeobox/POU domain protein 3A
brn-3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011143.4NP_035273.3  POU domain, class 4, transcription factor 1

    See identical proteins and their annotated locations for NP_035273.3

    Status: VALIDATED

    Source sequence(s)
    AC121997
    Consensus CDS
    CCDS27319.1
    UniProtKB/Swiss-Prot
    E9QPT6, P17208
    UniProtKB/TrEMBL
    Q78NA5
    Related
    ENSMUSP00000060798.8, ENSMUST00000053016.10
    Conserved Domains (2) summary
    smart00352
    Location:262339
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:360414
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    104699111..104705554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518706.4XP_006518769.1  POU domain, class 4, transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006518769.1

    UniProtKB/Swiss-Prot
    E9QPT6, P17208
    UniProtKB/TrEMBL
    Q78NA5
    Conserved Domains (2) summary
    smart00352
    Location:262339
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:360414
    Homeobox; Homeobox domain
  2. XM_006518705.4XP_006518768.1  POU domain, class 4, transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006518768.1

    UniProtKB/Swiss-Prot
    E9QPT6, P17208
    UniProtKB/TrEMBL
    Q78NA5
    Conserved Domains (2) summary
    smart00352
    Location:262339
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:360414
    Homeobox; Homeobox domain

RNA

  1. XR_383144.5 RNA Sequence