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Pole polymerase (DNA directed), epsilon [ Mus musculus (house mouse) ]

Gene ID: 18973, updated on 8-Feb-2024

Summary

Official Symbol
Poleprovided by MGI
Official Full Name
polymerase (DNA directed), epsilonprovided by MGI
Primary source
MGI:MGI:1196391
See related
Ensembl:ENSMUSG00000007080 AllianceGenome:MGI:1196391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA binding activity; catalytic activity, acting on DNA; and chromatin binding activity. Predicted to be involved in DNA metabolic process and G1/S transition of mitotic cell cycle. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of epsilon DNA polymerase complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 7.9), limb E14.5 (RPKM 6.6) and 18 other tissues See more
Orthologs
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Genomic context

See Pole in Genome Data Viewer
Location:
5 F; 5 53.45 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110434185..110485319)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110286319..110337468)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13949 Neighboring gene phosphoglycerate mutase family member 5 Neighboring gene peroxisomal membrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6363 Neighboring gene predicted gene, 26277 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 2 Neighboring gene leucine rich colipase-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA 3'-5' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in base-excision repair, gap-filling ISO
Inferred from Sequence Orthology
more info
 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair, DNA gap filling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of epsilon DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA polymerase epsilon catalytic subunit A
Names
3'-5' exodeoxyribonuclease
DNA polymerase II subunit A
DNA-directed DNA polymerase epsilon
pol-epsilon
NP_035262.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011132.2NP_035262.2  DNA polymerase epsilon catalytic subunit A

    See identical proteins and their annotated locations for NP_035262.2

    Status: VALIDATED

    Source sequence(s)
    AK141674, BC048166, CJ101052
    Consensus CDS
    CCDS19525.1
    UniProtKB/Swiss-Prot
    E9QKW1, Q9QX50, Q9WVF7
    UniProtKB/TrEMBL
    Q80XH7
    Related
    ENSMUSP00000007296.6, ENSMUST00000007296.12
    Conserved Domains (5) summary
    cd05779
    Location:268471
    DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
    cd05535
    Location:5311153
    POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
    COG0417
    Location:991165
    PolB; DNA polymerase elongation subunit (family B) [Replication, recombination and repair]
    pfam08490
    Location:15281924
    DUF1744; Domain of unknown function (DUF1744)
    cl00013
    Location:125231
    Lyase_I_like; Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110434185..110485319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)