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Pold1 polymerase (DNA directed), delta 1, catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 18971, updated on 5-Aug-2018

Summary

Official Symbol
Pold1provided by MGI
Official Full Name
polymerase (DNA directed), delta 1, catalytic subunitprovided by MGI
Primary source
MGI:MGI:97741
See related
Ensembl:ENSMUSG00000038644 Vega:OTTMUSG00000028995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
125kDa
Expression
Ubiquitous expression in thymus adult (RPKM 45.8), spleen adult (RPKM 30.6) and 25 other tissues See more
Orthologs

Genomic context

See Pold1 in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44532744..44548815, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51788114..51804185, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 71, member E1 Neighboring gene myosin binding protein C, fast-type Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene microRNA 7053 Neighboring gene nuclear receptor subfamily 1, group H, member 2 Neighboring gene napsin A aspartic peptidase Neighboring gene predicted gene 15396

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3'-5' exonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
3'-5'-exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication ISO
Inferred from Sequence Orthology
more info
 
DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication proofreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
DNA-dependent DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-dependent DNA replication ISO
Inferred from Sequence Orthology
more info
 
base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
base-excision repair, gap-filling IMP
Inferred from Mutant Phenotype
more info
PubMed 
base-excision repair, gap-filling ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-excision repair, DNA gap filling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
aggresome ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleotide-excision repair complex ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA polymerase delta catalytic subunit
Names
DNA polymerase delta 1, catalytic domain
NP_035261.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011131.3NP_035261.3  DNA polymerase delta catalytic subunit

    See identical proteins and their annotated locations for NP_035261.3

    Status: VALIDATED

    Source sequence(s)
    AK167569, BX634546, CJ173955
    Consensus CDS
    CCDS21210.1
    UniProtKB/Swiss-Prot
    P52431
    Related
    ENSMUSP00000039776.8, OTTMUSP00000036922, ENSMUST00000049343.14, OTTMUST00000071903
    Conserved Domains (4) summary
    cd05777
    Location:302531
    DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
    cd05533
    Location:577972
    POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
    PTZ00166
    Location:781098
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:10101080
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    44532744..44548815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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