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Pold1 polymerase (DNA directed), delta 1, catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 18971, updated on 8-Feb-2024

Summary

Official Symbol
Pold1provided by MGI
Official Full Name
polymerase (DNA directed), delta 1, catalytic subunitprovided by MGI
Primary source
MGI:MGI:97741
See related
Ensembl:ENSMUSG00000038644 AllianceGenome:MGI:97741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
125kDa
Summary
Enables 3'-5' exonuclease activity and enzyme binding activity. Involved in DNA biosynthetic process. Acts upstream of or within DNA replication proofreading and base-excision repair, gap-filling. Part of delta DNA polymerase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 45.8), spleen adult (RPKM 30.6) and 25 other tissues See more
Orthologs
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Genomic context

See Pold1 in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44182168..44198239, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44532744..44548815, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene golgi associated RAB2 interactor 5A Neighboring gene myosin binding protein C, fast-type Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene microRNA 7053 Neighboring gene STARR-positive B cell enhancer ABC_E1339 Neighboring gene STARR-positive B cell enhancer ABC_E8170 Neighboring gene STARR-positive B cell enhancer ABC_E2234 Neighboring gene nuclear receptor subfamily 1, group H, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E290 Neighboring gene napsin A aspartic peptidase Neighboring gene predicted gene 15396

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within DNA replication proofreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within base-excision repair, gap-filling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in base-excision repair, gap-filling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in error-free translesion synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair, DNA gap filling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of delta DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of delta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-excision repair complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA polymerase delta catalytic subunit
Names
3'-5' exodeoxyribonuclease
DNA polymerase delta 1, catalytic domain
NP_035261.3
XP_030098080.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011131.3NP_035261.3  DNA polymerase delta catalytic subunit

    See identical proteins and their annotated locations for NP_035261.3

    Status: VALIDATED

    Source sequence(s)
    AK167569, BX634546, CJ173955
    Consensus CDS
    CCDS21210.1
    UniProtKB/Swiss-Prot
    O54883, P52431, Q3TFX6
    UniProtKB/TrEMBL
    Q91VT0
    Related
    ENSMUSP00000039776.9, ENSMUST00000049343.15
    Conserved Domains (1) summary
    PTZ00166
    Location:781098
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44182168..44198239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242220.2XP_030098080.1  DNA polymerase delta catalytic subunit isoform X1

    UniProtKB/Swiss-Prot
    O54883, P52431, Q3TFX6
    UniProtKB/TrEMBL
    Q91VT0
    Conserved Domains (1) summary
    PTZ00166
    Location:781098
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional