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Septin4 septin 4 [ Mus musculus (house mouse) ]

Gene ID: 18952, updated on 1-Mar-2024

Summary

Official Symbol
Septin4provided by MGI
Official Full Name
septin 4provided by MGI
Primary source
MGI:MGI:1270156
See related
Ensembl:ENSMUSG00000020486 AllianceGenome:MGI:1270156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bh5; ARTS; Sept4; Pnutl2; Gm11492; hCDCREL-2
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and magnesium ion binding activity. Involved in flagellated sperm motility; neuron migration; and spermatid differentiation. Acts upstream of or within brain development; sperm capacitation; and sperm mitochondrion organization. Located in several cellular components, including dendrite; perikaryon; and sperm annulus. Part of septin complex. Is expressed in several structures, including central nervous system; olfactory epithelium; and retina. Orthologous to human SEPTIN4 (septin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 67.1), testis adult (RPKM 31.3) and 9 other tissues See more
Orthologs
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Genomic context

See Septin4 in Genome Data Viewer
Location:
11 C; 11 52.14 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87457515..87481365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87566689..87590543)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 14 intercellular bridge forming factor Neighboring gene STARR-seq mESC enhancer starr_30291 Neighboring gene small nucleolar RNA, C/D box 3B2 Neighboring gene STARR-seq mESC enhancer starr_30292 Neighboring gene predicted gene, 34000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87405102-87405211 Neighboring gene STARR-positive B cell enhancer ABC_E68 Neighboring gene STARR-seq mESC enhancer starr_30293 Neighboring gene myotubularin related protein 4 Neighboring gene heat shock transcription factor family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sperm capacitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sperm mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of septin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in sperm annulus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm annulus IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
septin-4
Names
CE5B3 beta
M-Septin
bradeion beta
brain protein H5
cell division control-related protein 2
cell division control-related protein 2b
peanut-like 2 homolog
peanut-like protein 2
septin H5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284392.2NP_001271321.1  septin-4 isoform 2

    See identical proteins and their annotated locations for NP_001271321.1

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Consensus CDS
    CCDS70277.1
    UniProtKB/Swiss-Prot
    P28661
    Related
    ENSMUSP00000060127.5, ENSMUST00000063156.11
    Conserved Domains (2) summary
    COG5019
    Location:25377
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:42315
    Septin; Septin
  2. NM_001284394.2NP_001271323.1  septin-4 isoform 3

    See identical proteins and their annotated locations for NP_001271323.1

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Consensus CDS
    CCDS70276.1
    UniProtKB/Swiss-Prot
    P28661
    Related
    ENSMUSP00000103594.2, ENSMUST00000107960.8
    Conserved Domains (1) summary
    pfam00735
    Location:141421
    Septin
  3. NM_001284398.2NP_001271327.1  septin-4 isoform 4

    See identical proteins and their annotated locations for NP_001271327.1

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Consensus CDS
    CCDS70275.1
    UniProtKB/Swiss-Prot
    P28661
    Related
    ENSMUSP00000112960.2, ENSMUST00000122067.8
    Conserved Domains (1) summary
    pfam00735
    Location:24296
    Septin
  4. NM_001361936.2NP_001348865.1  septin-4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Consensus CDS
    CCDS88214.1
    Related
    ENSMUSP00000103596.2, ENSMUST00000107962.8
    Conserved Domains (1) summary
    pfam00735
    Location:122402
    Septin
  5. NM_001368775.2NP_001355704.1  septin-4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Conserved Domains (2) summary
    pfam00735
    Location:635907
    Septin
    pfam15548
    Location:14509
    DUF4655; Domain of unknown function (DUF4655)
  6. NM_001368776.2NP_001355705.1  septin-4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Conserved Domains (1) summary
    pfam00735
    Location:135407
    Septin
  7. NM_001368777.2NP_001355706.1  septin-4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Related
    ENSMUST00000133638.8
    Conserved Domains (1) summary
    pfam00735
    Location:24296
    Septin
  8. NM_001368778.2NP_001355707.1  septin-4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Conserved Domains (1) summary
    pfam00735
    Location:122402
    Septin
  9. NM_001368779.2NP_001355708.1  septin-4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Conserved Domains (1) summary
    pfam00735
    Location:135407
    Septin
  10. NM_001424196.1NP_001411125.1  septin-4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL596086
    UniProtKB/TrEMBL
    A0A5F8MP96
  11. NM_011129.3NP_035259.1  septin-4 isoform 1

    See identical proteins and their annotated locations for NP_035259.1

    Status: VALIDATED

    Source sequence(s)
    AL596086
    Consensus CDS
    CCDS25213.1
    UniProtKB/Swiss-Prot
    B2KGM3, B2KGM6, P28661, Q3UVH1, Q3UZC3, Q5ND10, Q5ND15, Q5ND16, Q5ND19, Q7TPM7, Q80VX1
    Related
    ENSMUSP00000018544.6, ENSMUST00000018544.12
    Conserved Domains (1) summary
    pfam00735
    Location:141421
    Septin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87457515..87481365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245663.2XP_030101523.1  septin-4 isoform X2

    Conserved Domains (2) summary
    pfam15548
    Location:14509
    DUF4655; Domain of unknown function (DUF4655)
    cl38985
    Location:634759
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_030245665.2XP_030101525.1  septin-4 isoform X6

    Conserved Domains (1) summary
    pfam00735
    Location:35315
    Septin
  3. XM_036156427.1XP_036012320.1  septin-4 isoform X10

    Conserved Domains (1) summary
    pfam00735
    Location:1232
    Septin
  4. XM_036156428.1XP_036012321.1  septin-4 isoform X10

    Conserved Domains (1) summary
    pfam00735
    Location:1232
    Septin
  5. XM_036156425.1XP_036012318.1  septin-4 isoform X3

    Conserved Domains (1) summary
    pfam00735
    Location:134406
    Septin
  6. XM_036156426.1XP_036012319.1  septin-4 isoform X7

    Conserved Domains (1) summary
    pfam00735
    Location:35307
    Septin
  7. XM_030245666.2XP_030101526.1  septin-4 isoform X8

    Conserved Domains (1) summary
    pfam00735
    Location:43315
    Septin
  8. XM_030245664.2XP_030101524.1  septin-4 isoform X5

    Conserved Domains (1) summary
    pfam00735
    Location:131411
    Septin
  9. XM_006532497.4XP_006532560.1  septin-4 isoform X4

    See identical proteins and their annotated locations for XP_006532560.1

    Conserved Domains (1) summary
    pfam00735
    Location:131411
    Septin
  10. XM_030245667.1XP_030101527.1  septin-4 isoform X9

    Conserved Domains (1) summary
    pfam00735
    Location:1267
    Septin

RNA

  1. XR_004936842.1 RNA Sequence

  2. XR_004936843.1 RNA Sequence

  3. XR_004936844.1 RNA Sequence

  4. XR_388364.3 RNA Sequence

  5. XR_001779919.3 RNA Sequence