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Pld2 phospholipase D2 [ Mus musculus (house mouse) ]

Gene ID: 18806, updated on 22-Nov-2020

Summary

Official Symbol
Pld2provided by MGI
Official Full Name
phospholipase D2provided by MGI
Primary source
MGI:MGI:892877
See related
Ensembl:ENSMUSG00000020828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLD1C
Summary
This gene is a member of the phospholipase D (PLD) superfamily. The encoded protein catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. Phosphatidic acid is an essential intracellular lipid second messenger for many signaling pathways and has been implicated in a variety of physiological processes including cytoskeletal organization and cell proliferation. A similar gene in human may also function as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in lung adult (RPKM 7.1), subcutaneous fat pad adult (RPKM 6.6) and 27 other tissues See more
Orthologs

Genomic context

See Pld2 in Genome Data Viewer
Location:
11 B3; 11 42.99 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70430318..70448936)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70539492..70558110)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70353666..70371612)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 6 Neighboring gene predicted gene, 40193 Neighboring gene misshapen-like kinase 1 (zebrafish) Neighboring gene predicted gene, 51905 Neighboring gene RIKEN cDNA 4930544D05 gene Neighboring gene cholinergic receptor, nicotinic, epsilon polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase D activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol lipid-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipase D2
Names
choline phosphatase 2
phosphatidylcholine-hydrolyzing phospholipase D2
NP_001289404.1
NP_001289405.1
NP_001348864.1
NP_032902.1
XP_011247096.1
XP_011247097.1
XP_011247098.1
XP_011247099.1
XP_030101520.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302475.1NP_001289404.1  phospholipase D2 isoform 1

    See identical proteins and their annotated locations for NP_001289404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK143930, AL592547, AW047839
    Consensus CDS
    CCDS78979.1
    UniProtKB/TrEMBL
    Q3UNY4, Q6NV49
    Related
    ENSMUSP00000104197.3, ENSMUST00000108557.9
    Conserved Domains (4) summary
    PLN02866
    Location:67929
    PLN02866; phospholipase D
    cd01254
    Location:180309
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl02563
    Location:62192
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl15239
    Location:614806
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
  2. NM_001302476.1NP_001289405.1  phospholipase D2 isoform 3

    See identical proteins and their annotated locations for NP_001289405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' terminal exon which results in an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK143930, AL592547
    Consensus CDS
    CCDS78980.1
    UniProtKB/TrEMBL
    Q3UNY4, Q80ZW1
    Related
    ENSMUSP00000104196.1, ENSMUST00000108556.1
    Conserved Domains (3) summary
    cd01254
    Location:180309
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    pfam00169
    Location:206309
    PH; PH domain
    cl02563
    Location:62192
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  3. NM_001361935.1NP_001348864.1  phospholipase D2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK143930, AL592547, AW047839, BY772909
    Conserved Domains (1) summary
    PLN02866
    Location:67885
    PLN02866; phospholipase D
  4. NM_008876.3NP_032902.1  phospholipase D2 isoform 2

    See identical proteins and their annotated locations for NP_032902.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK143930, AL592547, AW047839
    Consensus CDS
    CCDS24953.1
    UniProtKB/Swiss-Prot
    P97813
    UniProtKB/TrEMBL
    Q3UNY4, Q5SXG5
    Related
    ENSMUSP00000018429.5, ENSMUST00000018429.11
    Conserved Domains (1) summary
    PLN02866
    Location:67918
    PLN02866; phospholipase D

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70430318..70448936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248796.3XP_011247098.1  phospholipase D2 isoform X3

    See identical proteins and their annotated locations for XP_011247098.1

    Conserved Domains (1) summary
    PLN02866
    Location:28879
    PLN02866; phospholipase D
  2. XM_011248794.3XP_011247096.1  phospholipase D2 isoform X1

    See identical proteins and their annotated locations for XP_011247096.1

    UniProtKB/Swiss-Prot
    P97813
    UniProtKB/TrEMBL
    Q5SXG5
    Conserved Domains (1) summary
    PLN02866
    Location:67918
    PLN02866; phospholipase D
  3. XM_030245660.1XP_030101520.1  phospholipase D2 isoform X5

  4. XM_011248795.3XP_011247097.1  phospholipase D2 isoform X2

    See identical proteins and their annotated locations for XP_011247097.1

    Conserved Domains (1) summary
    PLN02866
    Location:67885
    PLN02866; phospholipase D
  5. XM_011248797.3XP_011247099.1  phospholipase D2 isoform X4

    See identical proteins and their annotated locations for XP_011247099.1

    Conserved Domains (1) summary
    PLN02866
    Location:67868
    PLN02866; phospholipase D

RNA

  1. XR_001779917.3 RNA Sequence

  2. XR_001779918.3 RNA Sequence

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