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Plau plasminogen activator, urokinase [ Mus musculus (house mouse) ]

Gene ID: 18792, updated on 11-Apr-2024

Summary

Official Symbol
Plauprovided by MGI
Official Full Name
plasminogen activator, urokinaseprovided by MGI
Primary source
MGI:MGI:97611
See related
Ensembl:ENSMUSG00000021822 AllianceGenome:MGI:97611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
uPA; u-PA
Summary
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Predicted to be located in cell surface and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; fatty liver disease; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 100.9), bladder adult (RPKM 27.0) and 5 other tissues See more
Orthologs
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Genomic context

See Plau in Genome Data Viewer
Location:
14 A3; 14 11.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20886730..20893456)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20836662..20843388)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene STARR-seq mESC enhancer starr_36118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21604587-21604774 Neighboring gene STARR-seq mESC enhancer starr_36120 Neighboring gene predicted gene, 30108 Neighboring gene H3 histone, family 3A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7298 Neighboring gene STARR-seq mESC enhancer starr_36123 Neighboring gene STARR-seq mESC enhancer starr_36124 Neighboring gene predicted gene, 30212

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in fibrinolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fibrinolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibrinolysis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of plasminogen activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of fibrinolysis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of plasminogen activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in urokinase plasminogen activator signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein complex involved in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
part_of serine protease inhibitor complex ISO
Inferred from Sequence Orthology
more info
 
part_of serine-type endopeptidase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of serine-type endopeptidase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
urokinase-type plasminogen activator
Names
U-plasminogen activator
NP_032899.1
XP_017171408.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008873.3NP_032899.1  urokinase-type plasminogen activator precursor

    See identical proteins and their annotated locations for NP_032899.1

    Status: VALIDATED

    Source sequence(s)
    BY320655, X02389
    Consensus CDS
    CCDS26858.1
    UniProtKB/Swiss-Prot
    P06869
    UniProtKB/TrEMBL
    Q0VBA8
    Related
    ENSMUSP00000022368.3, ENSMUST00000022368.4
    Conserved Domains (2) summary
    cd00190
    Location:180424
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:71152
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20886730..20893456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315919.3XP_017171408.1  urokinase-type plasminogen activator isoform X1

    UniProtKB/Swiss-Prot
    P06869
    UniProtKB/TrEMBL
    Q0VBA8
    Conserved Domains (2) summary
    cd00190
    Location:180424
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:71152
    Kringle; Kringle domain