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Prkch protein kinase C, eta [ Mus musculus (house mouse) ]

Gene ID: 18755, updated on 8-Feb-2024

Summary

Official Symbol
Prkchprovided by MGI
Official Full Name
protein kinase C, etaprovided by MGI
Primary source
MGI:MGI:97600
See related
Ensembl:ENSMUSG00000021108 AllianceGenome:MGI:97600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkch
Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in lung adult (RPKM 17.2), thymus adult (RPKM 13.2) and 21 other tissues See more
Orthologs
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Genomic context

See Prkch in Genome Data Viewer
Location:
12 C3; 12 30.81 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (73631570..73824959)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73584796..73778185)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2210039B01 gene Neighboring gene transmembrane protein 30B Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:74699241-74699512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:74705920-74706029 Neighboring gene STARR-seq mESC enhancer starr_32475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:74880254-74880437 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:74880601-74880802 Neighboring gene predicted gene, 34189 Neighboring gene predicted gene 8075 Neighboring gene STARR-seq mESC enhancer starr_32478 Neighboring gene STARR-seq mESC enhancer starr_32479 Neighboring gene hypoxia inducible factor 1, alpha subunit Neighboring gene predicted gene 15283

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables translation regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C eta type
Names
PKC-L
nPKC-eta
NP_001300906.1
NP_032882.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313977.1NP_001300906.1  protein kinase C eta type isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC124179, AK164044, BF462787
    UniProtKB/TrEMBL
    Q3U1I0
    Conserved Domains (2) summary
    cd05590
    Location:246568
    STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
    pfam00130
    Location:133185
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. NM_008856.4NP_032882.2  protein kinase C eta type isoform 1

    See identical proteins and their annotated locations for NP_032882.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC124179, AK145817, AK164044, BF462787
    Consensus CDS
    CCDS25976.1
    UniProtKB/Swiss-Prot
    P23298, Q8K2K8
    UniProtKB/TrEMBL
    Q3UKY1
    Related
    ENSMUSP00000021527.9, ENSMUST00000021527.15
    Conserved Domains (3) summary
    cd04014
    Location:8140
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05590
    Location:359681
    STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
    pfam00130
    Location:246296
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    73631570..73824959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)