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Prkch protein kinase C, eta [ Mus musculus (house mouse) ]

Gene ID: 18755, updated on 5-Aug-2018

Summary

Official Symbol
Prkchprovided by MGI
Official Full Name
protein kinase C, etaprovided by MGI
Primary source
MGI:MGI:97600
See related
Ensembl:ENSMUSG00000021108 Vega:OTTMUSG00000029341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkch
Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in lung adult (RPKM 17.2), thymus adult (RPKM 13.2) and 21 other tissues See more
Orthologs

Genomic context

See Prkch in Genome Data Viewer
Location:
12; 12 C3
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (73584796..73778185)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (74686028..74879172)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2210039B01 gene Neighboring gene transmembrane protein 30B Neighboring gene predicted gene, 34189 Neighboring gene predicted gene 8075 Neighboring gene hypoxia inducible factor 1, alpha subunit Neighboring gene predicted gene 15283

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Ral GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium-independent protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C eta type
Names
PKC-L
nPKC-eta
NP_001300906.1
NP_032882.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313977.1NP_001300906.1  protein kinase C eta type isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC124179, AK164044, BF462787
    UniProtKB/Swiss-Prot
    P23298
    Conserved Domains (2) summary
    cd05590
    Location:246568
    STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
    pfam00130
    Location:133185
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. NM_008856.4NP_032882.2  protein kinase C eta type isoform 1

    See identical proteins and their annotated locations for NP_032882.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC124179, AK145817, AK164044, BF462787
    Consensus CDS
    CCDS25976.1
    UniProtKB/Swiss-Prot
    P23298
    UniProtKB/TrEMBL
    Q3UKY1
    Related
    ENSMUSP00000021527.8, OTTMUSP00000037480, ENSMUST00000021527.14, OTTMUST00000072699
    Conserved Domains (3) summary
    cd04014
    Location:8140
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05590
    Location:359681
    STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
    pfam00130
    Location:246298
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    73584796..73778185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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