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Pirb paired Ig-like receptor B [ Mus musculus (house mouse) ]

Gene ID: 18733, updated on 11-Apr-2024

Summary

Official Symbol
Pirbprovided by MGI
Official Full Name
paired Ig-like receptor Bprovided by MGI
Primary source
MGI:MGI:894311
See related
Ensembl:ENSMUSG00000058818 AllianceGenome:MGI:894311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gp91; LIR-3; PIR-B; Lilrb3
Summary
Enables amyloid-beta binding activity and protein homodimerization activity. Involved in learning or memory; regulation of protein metabolic process; and regulation of synaptic plasticity. Acts upstream of or within several processes, including B cell homeostasis; B cell mediated immunity; and myeloid dendritic cell differentiation. Predicted to be located in cytoplasm; external side of plasma membrane; and extracellular space. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and ganglionic eminence. Orthologous to several human genes including LILRB5 (leukocyte immunoglobulin like receptor B5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 40.8), mammary gland adult (RPKM 24.0) and 14 other tissues See more
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Genomic context

See Pirb in Genome Data Viewer
Location:
7 A1; 7 2.14 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3715504..3723381, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3712505..3720382, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene STARR-positive B cell enhancer ABC_E2812 Neighboring gene ribosomal protein S9 Neighboring gene STARR-positive B cell enhancer mm9_chr7:3672088-3672388 Neighboring gene paired-Ig-like receptor A1 Neighboring gene paired-Ig-like receptor A2, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables HLA-A specific inhibitory MHC class I receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables HLA-B specific inhibitory MHC class I receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables MHC class Ib protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class Ib protein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class Ib receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inhibitory MHC class I receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in learning or memory IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of long-term synaptic depression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein dephosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily B member 3
Names
cell-surface glycoprotein p91
leukocyte immunoglobulin-like receptor 3
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
paired immunoglobulin-like receptor B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357394.1NP_001344323.1  leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK142375, AK161081, BB842214
    UniProtKB/TrEMBL
    Q8R2Z1
    Conserved Domains (1) summary
    cl11960
    Location:225315
    Ig; Immunoglobulin domain
  2. NM_011095.2NP_035225.2  leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035225.2

    Status: VALIDATED

    Source sequence(s)
    AF148880, AK161081, AK165255
    Consensus CDS
    CCDS39730.1
    UniProtKB/Swiss-Prot
    P97484
    UniProtKB/TrEMBL
    Q8R2Z1
    Related
    ENSMUSP00000077546.7, ENSMUST00000078451.7
    Conserved Domains (2) summary
    smart00410
    Location:529617
    IG_like; Immunoglobulin like
    cl11960
    Location:225315
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3715504..3723381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539634.4XP_006539697.1  leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1

    UniProtKB/TrEMBL
    Q8R2Z1
    Conserved Domains (1) summary
    cl11960
    Location:225315
    Ig; Immunoglobulin domain
  2. XM_006539635.4XP_006539698.1  leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:126220
    Ig; Immunoglobulin domain

RNA

  1. XR_003946417.1 RNA Sequence