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Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 18709, updated on 7-May-2024

Summary

Official Symbol
Pik3r2provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 2provided by MGI
Primary source
MGI:MGI:1098772
See related
Ensembl:ENSMUSG00000031834 AllianceGenome:MGI:1098772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p85beta
Summary
Enables phosphatidylinositol 3-kinase regulatory subunit binding activity and protein heterodimerization activity. Involved in several processes, including cellular glucose homeostasis; insulin receptor signaling pathway; and positive regulation of protein import into nucleus. Acts upstream of or within positive regulation of cell adhesion; regulation of actin filament organization; and regulation of protein localization to plasma membrane. Located in focal adhesion and nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; musculature; and spleen. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 65.5), duodenum adult (RPKM 57.1) and 28 other tissues See more
Orthologs
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Genomic context

See Pik3r2 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71220820..71229356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70768176..70776712, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330537M06 gene Neighboring gene STARR-positive B cell enhancer ABC_E190 Neighboring gene MPV17 mitochondrial membrane protein-like 2 Neighboring gene interferon gamma inducible protein 30 Neighboring gene STARR-positive B cell enhancer ABC_E10506 Neighboring gene RIKEN cDNA 2010320M18 gene Neighboring gene STARR-positive B cell enhancer ABC_E8241 Neighboring gene STARR-positive B cell enhancer ABC_E6649 Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E2265 Neighboring gene microRNA 7240

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol 3-kinase regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphatidylinositol 3-kinase complex, class IA ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylinositol 3-kinase regulatory subunit beta
Names
PI3-kinase regulatory subunit beta
PI3-kinase subunit p85-beta
PI3K regulatory subunit beta
phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
ptdIns-3-kinase regulatory subunit p85-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424805.1NP_001411734.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162446
  2. NM_001424806.1NP_001411735.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162446
  3. NM_008841.3NP_032867.2  phosphatidylinositol 3-kinase regulatory subunit beta isoform 1

    See identical proteins and their annotated locations for NP_032867.2

    Status: VALIDATED

    Source sequence(s)
    AC162446
    Consensus CDS
    CCDS22381.1
    UniProtKB/Swiss-Prot
    O08908, Q5U3K7
    UniProtKB/TrEMBL
    A0A2X0SZ21
    Related
    ENSMUSP00000034296.9, ENSMUST00000034296.15
    Conserved Domains (6) summary
    cd09930
    Location:609712
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:316426
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:780
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:431591
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    pfam16454
    Location:430589
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl02570
    Location:111289
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71220820..71229356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)