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Abcb4 ATP-binding cassette, sub-family B member 4 [ Mus musculus (house mouse) ]

Gene ID: 18670, updated on 20-Feb-2024

Summary

Official Symbol
Abcb4provided by MGI
Official Full Name
ATP-binding cassette, sub-family B member 4provided by MGI
Primary source
MGI:MGI:97569
See related
Ensembl:ENSMUSG00000042476 AllianceGenome:MGI:97569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdr2; Pgy2; Pgy-2; mdr-2
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 22.1), liver E18 (RPKM 18.3) and 5 other tissues See more
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Genomic context

See Abcb4 in Genome Data Viewer
Location:
5 A1; 5 3.43 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8943614..9009226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8893614..8959226)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157 Neighboring gene STARR-seq mESC enhancer starr_12393 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B member 1B Neighboring gene STARR-seq mESC enhancer starr_12396 Neighboring gene STARR-seq mESC enhancer starr_12398 Neighboring gene STARR-seq mESC enhancer starr_12399 Neighboring gene STARR-positive B cell enhancer ABC_E6299 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388 Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene carnitine O-octanoyltransferase Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene predicted gene, 40264

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine floppase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylcholine floppase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bile acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to bile acid ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fenofibrate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in xenobiotic transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
phosphatidylcholine translocator ABCB4
Names
ATP-binding cassette, sub-family B (MDR/TAP), member 4
P glycoprotein 2
P-glycoprotein 3
multidrug resistance protein 2
multidrug resistance protein 3
NP_032856.2
XP_006503614.1
XP_006503615.1
XP_006503617.1
XP_036020767.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008830.2NP_032856.2  phosphatidylcholine translocator ABCB4

    See identical proteins and their annotated locations for NP_032856.2

    Status: VALIDATED

    Source sequence(s)
    AA239419, AK050345, AK144024, CB951185, CJ071650, CX204859
    Consensus CDS
    CCDS19086.1
    UniProtKB/Swiss-Prot
    B9EK77, P21440, Q6LCL9
    Related
    ENSMUSP00000003717.9, ENSMUST00000003717.13
    Conserved Domains (3) summary
    cd03249
    Location:392628
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:301269
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:58342
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8943614..9009226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503552.2XP_006503615.1  phosphatidylcholine translocator ABCB4 isoform X2

    Conserved Domains (1) summary
    PTZ00265
    Location:11216
    PTZ00265; multidrug resistance protein (mdr1); Provisional
  2. XM_006503551.5XP_006503614.1  phosphatidylcholine translocator ABCB4 isoform X1

    Conserved Domains (2) summary
    cd03249
    Location:392628
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:301203
    PTZ00265; multidrug resistance protein (mdr1); Provisional
  3. XM_036164874.1XP_036020767.1  phosphatidylcholine translocator ABCB4 isoform X3

    Conserved Domains (1) summary
    PTZ00265
    Location:141111
    PTZ00265; multidrug resistance protein (mdr1); Provisional
  4. XM_006503554.4XP_006503617.1  phosphatidylcholine translocator ABCB4 isoform X4

    Conserved Domains (1) summary
    PTZ00265
    Location:371052
    PTZ00265; multidrug resistance protein (mdr1); Provisional