U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pgk1 phosphoglycerate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18655, updated on 5-Feb-2023

Summary

Official Symbol
Pgk1provided by MGI
Official Full Name
phosphoglycerate kinase 1provided by MGI
Primary source
MGI:MGI:97555
See related
Ensembl:ENSMUSG00000062070 AllianceGenome:MGI:97555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgk-1
Summary
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in placenta adult (RPKM 206.0), liver E18 (RPKM 170.7) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pgk1 in Genome Data Viewer
Location:
X D; X 47.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105230706..105247305)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106187100..106203699)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene toll-like receptor 13 Neighboring gene TM2 domain containing 2 pseudogene Neighboring gene TATA-box binding protein associated factor 9B Neighboring gene fibronectin type III domain containing 3C2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118097

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoglycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoglycerate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoglycerate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-disulfide reductase (NAD(P)) activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in canonical glycolysis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphoglycerate kinase 1
NP_032854.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008828.3NP_032854.2  phosphoglycerate kinase 1

    See identical proteins and their annotated locations for NP_032854.2

    Status: REVIEWED

    Source sequence(s)
    AK133877, BE986846, BY292706
    Consensus CDS
    CCDS30339.1
    UniProtKB/Swiss-Prot
    P09411, Q5XJE7
    UniProtKB/TrEMBL
    A0A8C6GT87
    Related
    ENSMUSP00000080302.7, ENSMUST00000081593.13
    Conserved Domains (1) summary
    PTZ00005
    Location:3416
    PTZ00005; phosphoglycerate kinase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    105230706..105247305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)