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Pgk1 phosphoglycerate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18655, updated on 8-Jul-2018
Official Symbol
Pgk1provided by MGI
Official Full Name
phosphoglycerate kinase 1provided by MGI
Primary source
MGI:MGI:97555
See related
Ensembl:ENSMUSG00000062070 Vega:OTTMUSG00000018277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgk-1
Summary
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in placenta adult (RPKM 206.0), liver E18 (RPKM 170.7) and 27 other tissues See more
Orthologs
See Pgk1 in Genome Data Viewer
Location:
X D; X 47.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (106187100..106203699)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (103382463..103399038)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene toll-like receptor 13 Neighboring gene TM2 domain containing 2 pseudogene Neighboring gene TATA-box binding protein associated factor 9B Neighboring gene fibronectin type III domain containing 3C2

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC118097

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphoglycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoglycerate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoglycerate kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
glycolytic process ISO
Inferred from Sequence Orthology
more info
 
muscle cell cellular homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatic muscle development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
phosphoglycerate kinase 1
NP_032854.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008828.3NP_032854.2  phosphoglycerate kinase 1

    See identical proteins and their annotated locations for NP_032854.2

    Status: REVIEWED

    Source sequence(s)
    AK133877, BE986846, BY292706
    Consensus CDS
    CCDS30339.1
    UniProtKB/Swiss-Prot
    P09411
    Related
    ENSMUSP00000080302.6, OTTMUSP00000019855, ENSMUST00000081593.12, OTTMUST00000044166
    Conserved Domains (1) summary
    PTZ00005
    Location:3416
    PTZ00005; phosphoglycerate kinase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    106187100..106203699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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