U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 [ Mus musculus (house mouse) ]

Gene ID: 18604, updated on 12-May-2024

Summary

Official Symbol
Pdk2provided by MGI
Official Full Name
pyruvate dehydrogenase kinase, isoenzyme 2provided by MGI
Primary source
MGI:MGI:1343087
See related
Ensembl:ENSMUSG00000038967 AllianceGenome:MGI:1343087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including insulin receptor signaling pathway; regulation of acetyl-CoA biosynthetic process from pyruvate; and regulation of gluconeogenesis. Acts upstream of or within regulation of calcium-mediated signaling. Located in mitochondrion. Part of mitochondrial pyruvate dehydrogenase complex. Is expressed in heart. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 156.0), kidney adult (RPKM 138.3) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pdk2 in Genome Data Viewer
Location:
11 D; 11 59.01 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94917084..94932197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95026258..95041371, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 9B Neighboring gene predicted gene, 51875 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene predicted gene, 53200 Neighboring gene STARR-positive B cell enhancer ABC_E9839 Neighboring gene predicted gene 11513 Neighboring gene predicted gene, 53644 Neighboring gene integrin alpha 3 Neighboring gene predicted gene, 53645 Neighboring gene distal-less homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase kinase, isoenzyme 2
Names
PDH kinase 2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
pyruvate dehydrogenase 2
pyruvate dehydrogenase kinase, isozyme 2
NP_001348844.1
NP_598428.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361915.1NP_001348844.1  pyruvate dehydrogenase kinase, isoenzyme 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI848783, BE647354, CK618575, CN538500, CX204954, CX208144
    Conserved Domains (2) summary
    cd16929
    Location:132297
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:1128
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
  2. NM_133667.2NP_598428.2  pyruvate dehydrogenase kinase, isoenzyme 2 isoform 1

    See identical proteins and their annotated locations for NP_598428.2

    Status: VALIDATED

    Source sequence(s)
    AF267660, AI848783, CK618575, CX204954, CX223857
    Consensus CDS
    CCDS25270.1
    UniProtKB/Swiss-Prot
    Q8VC63, Q9JK42
    Related
    ENSMUSP00000041447.8, ENSMUST00000038431.8
    Conserved Domains (2) summary
    pfam10436
    Location:30192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
    cd16929
    Location:196361
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94917084..94932197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)