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Pde9a phosphodiesterase 9A [ Mus musculus (house mouse) ]

Gene ID: 18585, updated on 17-Jul-2018

Summary

Official Symbol
Pde9aprovided by MGI
Official Full Name
phosphodiesterase 9Aprovided by MGI
Primary source
MGI:MGI:1277179
See related
Ensembl:ENSMUSG00000041119 Vega:OTTMUSG00000033902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PDE9A1
Expression
Broad expression in colon adult (RPKM 62.7), large intestine adult (RPKM 61.1) and 19 other tissues See more
Orthologs

Genomic context

See Pde9a in Genome Data Viewer
Location:
17; 17 B1
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (31386212..31476310)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (31523179..31613254)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30139 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene WD repeat domain 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cGMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cGMP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cGMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
cGMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
NP_001157220.1
NP_032830.3
XP_006523884.1
XP_017172808.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163748.1NP_001157220.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

    See identical proteins and their annotated locations for NP_001157220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK030509, BC061163, BY283127
    Consensus CDS
    CCDS28605.1
    UniProtKB/Swiss-Prot
    O70628
    UniProtKB/TrEMBL
    Q8BSU4
    Related
    ENSMUSP00000117611.1, OTTMUSP00000046197, ENSMUST00000127929.7, OTTMUST00000085511
    Conserved Domains (1) summary
    pfam00233
    Location:250478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_008804.4NP_032830.3  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

    See identical proteins and their annotated locations for NP_032830.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC166172, AK030509, BY283127
    Consensus CDS
    CCDS28605.1
    UniProtKB/Swiss-Prot
    O70628
    UniProtKB/TrEMBL
    Q8BSU4
    Related
    ENSMUSP00000038005.5, OTTMUSP00000046196, ENSMUST00000047168.11, OTTMUST00000085510
    Conserved Domains (1) summary
    pfam00233
    Location:250478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    31386212..31476310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317319.1XP_017172808.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:103331
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. XM_006523821.2XP_006523884.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    See identical proteins and their annotated locations for XP_006523884.1

    Conserved Domains (1) summary
    pfam00233
    Location:103331
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RNA

  1. XR_001782057.1 RNA Sequence

    Related
    ENSMUST00000124902.7, OTTMUST00000085517
  2. XR_001782058.1 RNA Sequence

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