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Pdcd6ip programmed cell death 6 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 18571, updated on 8-Jan-2023

Summary

Official Symbol
Pdcd6ipprovided by MGI
Official Full Name
programmed cell death 6 interacting proteinprovided by MGI
Primary source
MGI:MGI:1333753
See related
Ensembl:ENSMUSG00000032504 AllianceGenome:MGI:1333753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aip1; Alix; Eig2; mKIAA1375
Summary
Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including actomyosin contractile ring assembly; bicellular tight junction assembly; and maintenance of epithelial cell apical/basal polarity. Located in actomyosin; cytosol; and extracellular exosome. Is expressed in hindgut; midgut; rectum; and thymus primordium. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 72.0), colon adult (RPKM 53.1) and 28 other tissues See more
Orthologs
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Genomic context

See Pdcd6ip in Genome Data Viewer
Location:
9; 9 F3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (113480812..113537457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (113651744..113708279, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36686 Neighboring gene predicted gene, 36745 Neighboring gene predicted gene, 38623 Neighboring gene CLIP associating protein 2 Neighboring gene predicted gene, 25059

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables proteinase activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular exosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extracellular exosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
 
located_in actomyosin IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
programmed cell death 6-interacting protein
Names
ALG-2-interacting protein 1
ALG-2-interacting protein X
Alg2-interacting protein 1
Alg2-interacting protein X
E2f1-inducible protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164677.1NP_001158149.1  programmed cell death 6-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001158149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC167246, AK029827, AK031256, AK157704, AK167574, BE623112, BM899382
    Consensus CDS
    CCDS52947.1
    UniProtKB/Swiss-Prot
    Q9WU78
    Related
    ENSMUSP00000107492.4, ENSMUST00000111861.4
    Conserved Domains (4) summary
    cd09235
    Location:365703
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:2350
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    pfam12273
    Location:821874
    RCR; Chitin synthesis regulation, resistance to Congo red
    pfam13949
    Location:417706
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
  2. NM_001164678.1NP_001158150.1  programmed cell death 6-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_001158150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC167246, AK029827, AK157704, AK167574, BE623112, BM899382, CX210461
    UniProtKB/Swiss-Prot
    Q9WU78
    UniProtKB/TrEMBL
    Q80Y09
    Conserved Domains (4) summary
    cd09235
    Location:360698
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:2345
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    pfam12273
    Location:819872
    RCR; Chitin synthesis regulation, resistance to Congo red
    pfam13949
    Location:412701
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
  3. NM_011052.2NP_035182.2  programmed cell death 6-interacting protein isoform 3

    See identical proteins and their annotated locations for NP_035182.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC167246, AK029827, AK157704, AK167574, BE623112, BM899382
    Consensus CDS
    CCDS23588.1
    UniProtKB/Swiss-Prot
    Q9QZN8, Q9WU78
    Related
    ENSMUSP00000035086.7, ENSMUST00000035086.13
    Conserved Domains (4) summary
    cd09235
    Location:360698
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:2345
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    pfam12273
    Location:816869
    RCR; Chitin synthesis regulation, resistance to Congo red
    pfam13949
    Location:412701
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    113480812..113537457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242941.4XP_011241243.1  programmed cell death 6-interacting protein isoform X1

    Conserved Domains (3) summary
    cd09235
    Location:365703
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:2350
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    smart00818
    Location:823877
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
  2. XM_030244125.2XP_030099985.1  programmed cell death 6-interacting protein isoform X3

    Conserved Domains (3) summary
    cd09235
    Location:170508
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    smart00818
    Location:628682
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cl14649
    Location:1155
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
  3. XM_036154688.1XP_036010581.1  programmed cell death 6-interacting protein isoform X2

    Conserved Domains (3) summary
    cd09235
    Location:175513
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    smart00818
    Location:633687
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cl14649
    Location:1160
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains