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DVL3 dishevelled segment polarity protein 3 [ Homo sapiens (human) ]

Gene ID: 1857, updated on 22-Nov-2020

Summary

Official Symbol
DVL3provided by HGNC
Official Full Name
dishevelled segment polarity protein 3provided by HGNC
Primary source
HGNC:HGNC:3087
See related
Ensembl:ENSG00000161202 MIM:601368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRS3
Summary
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 25.5), endometrium (RPKM 18.5) and 25 other tissues See more
Orthologs

Genomic context

See DVL3 in Genome Data Viewer
Location:
3q27.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184155311..184173614)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183873099..183891314)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene EIF2B5 divergent transcript Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene ribosomal protein S3 pseudogene 3 Neighboring gene adaptor related protein complex 2 subunit mu 1 Neighboring gene ATP binding cassette subfamily F member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
frizzled binding TAS
Traceable Author Statement
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
non-canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
non-canonical Wnt signaling pathway via JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
planar cell polarity pathway involved in neural tube closure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
segment polarity protein dishevelled homolog DVL-3
Names
dishevelled 3 (homologous to Drosophila dsh)
dishevelled, dsh homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046860.1 RefSeqGene

    Range
    5067..23304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004423.4NP_004414.3  segment polarity protein dishevelled homolog DVL-3

    See identical proteins and their annotated locations for NP_004414.3

    Status: REVIEWED

    Source sequence(s)
    AC131235, D86963, U75651
    Consensus CDS
    CCDS3253.1
    UniProtKB/Swiss-Prot
    Q92997
    Related
    ENSP00000316054.3, ENST00000313143.9
    Conserved Domains (5) summary
    smart00021
    Location:182
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:97245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    184155311..184173614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247172.2XP_005247229.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

    See identical proteins and their annotated locations for XP_005247229.1

    Conserved Domains (5) summary
    smart00021
    Location:182
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:97245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
  2. XM_011512513.2XP_011510815.1  segment polarity protein dishevelled homolog DVL-3 isoform X2

    See identical proteins and their annotated locations for XP_011510815.1

    UniProtKB/TrEMBL
    Q9UG07
    Conserved Domains (3) summary
    cd00992
    Location:79166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:245328
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam12316
    Location:332538
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
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