Format

Send to:

Choose Destination

DVL3 dishevelled segment polarity protein 3 [ Homo sapiens (human) ]

Gene ID: 1857, updated on 5-Jan-2022

Summary

Official Symbol
DVL3provided by HGNC
Official Full Name
dishevelled segment polarity protein 3provided by HGNC
Primary source
HGNC:HGNC:3087
See related
Ensembl:ENSG00000161202 MIM:601368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRS3
Summary
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 25.5), endometrium (RPKM 18.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DVL3 in Genome Data Viewer
Location:
3q27.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184155377..184173614)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183873165..183891402)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene EIF2B5 divergent transcript Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene ribosomal protein S3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 1463 Neighboring gene Sharpr-MPRA regulatory region 464 Neighboring gene adaptor related protein complex 2 subunit mu 1 Neighboring gene ATP binding cassette subfamily F member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables frizzled binding TAS
Traceable Author Statement
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in non-canonical Wnt signaling pathway via JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in planar cell polarity pathway involved in neural tube closure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
segment polarity protein dishevelled homolog DVL-3
Names
dishevelled 3 (homologous to Drosophila dsh)
dishevelled, dsh homolog 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046860.1 RefSeqGene

    Range
    5067..23304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1269

mRNA and Protein(s)

  1. NM_004423.4NP_004414.3  segment polarity protein dishevelled homolog DVL-3

    See identical proteins and their annotated locations for NP_004414.3

    Status: REVIEWED

    Source sequence(s)
    AC131235, D86963, U75651
    Consensus CDS
    CCDS3253.1
    UniProtKB/Swiss-Prot
    Q92997
    Related
    ENSP00000316054.3, ENST00000313143.9
    Conserved Domains (5) summary
    smart00021
    Location:182
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:92245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    184155377..184173614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center