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Pdcd2 programmed cell death 2 [ Mus musculus (house mouse) ]

Gene ID: 18567, updated on 9-Nov-2022

Summary

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Official Symbol
Pdcd2provided by MGI
Official Full Name
programmed cell death 2provided by MGI
Primary source
MGI:MGI:104643
See related
Ensembl:ENSMUSG00000014771 AllianceGenome:MGI:104643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcd2; RP-8
Summary
Predicted to enable enzyme binding activity. Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of hematopoietic stem cell proliferation; and regulation of hematopoietic progenitor cell differentiation. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in cranial ganglion; cranial nerve; and dorsal root ganglion. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 26.0), adrenal adult (RPKM 24.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pdcd2 in Genome Data Viewer
Location:
17 A2; 17 8.95 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15737561..15749608, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15521575..15527319, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120, member B Neighboring gene predicted gene, 49668 Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 Neighboring gene TATA box binding protein Neighboring gene zinc finger protein 91 pseudogene Neighboring gene PR domain containing 9 Neighboring gene BRCA1 associated RING domain 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance. Mu W, et al. Dev Biol, 2010 Nov 15. PMID 20813103, Free PMC Article
  2. Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells. Vaux DL, et al. DNA Cell Biol, 1995 Mar. PMID 7880439
  3. Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest. Granier CJ, et al. Biol Open, 2014 Aug 22. PMID 25150276, Free PMC Article
  4. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Baron BW, et al. Proc Natl Acad Sci U S A, 2007 May 1. PMID 17468402, Free PMC Article
  5. Conserved alternative and antisense transcripts at the programmed cell death 2 locus. Mihola O, et al. BMC Genomics, 2007 Jan 18. PMID 17233890, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pdcd2(-/-) embryos underwent implantation but did not undergo further development. Inner cell masses from Pdcd2(-/-) blastocysts failed to outgrow in vitro.
    Title: PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.
  2. repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas
    Title: Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
programmed cell death protein 2
Names
zinc finger protein Rp-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412856.1 → NP_001399785.1  programmed cell death protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154378

  2. NM_001412857.1 → NP_001399786.1  programmed cell death protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154378

  3. NM_001412858.1 → NP_001399787.1  programmed cell death protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154378

  4. NM_001412859.1 → NP_001399788.1  programmed cell death protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154378

  5. NM_001412860.1 → NP_001399789.1  programmed cell death protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154378

  6. NM_001412861.1 → NP_001399790.1  programmed cell death protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154378
    UniProtKB/TrEMBL
    A2T4N6

  7. NM_001412862.1 → NP_001399791.1  programmed cell death protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154378

  8. NM_008799.3 → NP_032825.2  programmed cell death protein 2 isoform 1

    See identical proteins and their annotated locations for NP_032825.2

    Status: VALIDATED

    Source sequence(s)
    AC154378
    Consensus CDS
    CCDS28413.1
    UniProtKB/Swiss-Prot
    P46718
    UniProtKB/TrEMBL
    A0A0R4J0N5
    Related
    ENSMUSP00000052523.7, ENSMUST00000054450.7
    Conserved Domains (2) summary
    pfam01753
    Location:134 → 171
    zf-MYND; MYND finger
    pfam04194
    Location:225 → 338
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

RNA

  1. NR_182059.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154378

  2. NR_182060.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154378

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    15737561..15749608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160397.1 → XP_036016290.1  programmed cell death protein 2 isoform X1

    Related
    ENSMUSP00000118625.2, ENSMUST00000154293.8
    Conserved Domains (2) summary
    pfam01753
    Location:134 → 171
    zf-MYND; MYND finger
    pfam04194
    Location:223 → 253
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

  2. XM_030249571.2 → XP_030105431.1  programmed cell death protein 2 isoform X2

    Conserved Domains (2) summary
    pfam01753
    Location:1 → 29
    zf-MYND; MYND finger
    pfam04194
    Location:81 → 196
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46718.2 GenPept UniProtKB/Swiss-Prot:P46718

Gene LinkOut

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