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Pcx pyruvate carboxylase [ Mus musculus (house mouse) ]

Gene ID: 18563, updated on 5-Mar-2024

Summary

Official Symbol
Pcxprovided by MGI
Official Full Name
pyruvate carboxylaseprovided by MGI
Primary source
MGI:MGI:97520
See related
Ensembl:ENSMUSG00000024892 AllianceGenome:MGI:97520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pc; Pcb
Summary
Predicted to enable anion binding activity; identical protein binding activity; and pyruvate carboxylase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; gluconeogenesis; and viral RNA genome packaging. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 255.0), adrenal adult (RPKM 223.4) and 13 other tissues See more
Orthologs
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Genomic context

See Pcx in Genome Data Viewer
Location:
19 A; 19 4.07 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4560500..4671780)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4510472..4621752)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930001C03 gene Neighboring gene synaptotagmin XII Neighboring gene RIKEN cDNA 2010003K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E778 Neighboring gene STARR-seq mESC enhancer starr_45350 Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene microRNA 6986 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene Ras converting CAAX endopeptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables biotin binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables pyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyruvate carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pyruvate carboxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in viral RNA genome packaging ISO
Inferred from Sequence Orthology
more info
 
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyruvate carboxylase, mitochondrial
Names
pyruvate decarboxylase
pyruvic carboxylase
NP_001156418.1
NP_032823.2
XP_006531741.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162946.1NP_001156418.1  pyruvate carboxylase, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA619324, AK077665, AK148328, BG087228, BY230152, BY293312
    Consensus CDS
    CCDS50352.1
    UniProtKB/TrEMBL
    E9QPD7, Q3T9S7, Q3TCQ3
    Related
    ENSMUSP00000063825.7, ENSMUST00000068004.13
    Conserved Domains (1) summary
    PRK12999
    Location:341179
    PRK12999; pyruvate carboxylase; Reviewed
  2. NM_008797.3NP_032823.2  pyruvate carboxylase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_032823.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA619324, AK077665, AK148328, BG087228, BY059816, BY139237
    Consensus CDS
    CCDS29430.1
    UniProtKB/Swiss-Prot
    Q05920
    UniProtKB/TrEMBL
    G5E8R3
    Related
    ENSMUSP00000109456.3, ENSMUST00000113825.4
    Conserved Domains (1) summary
    PRK12999
    Location:331178
    PRK12999; pyruvate carboxylase; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4560500..4671780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531678.5XP_006531741.1  pyruvate carboxylase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531741.1

    UniProtKB/Swiss-Prot
    Q05920
    UniProtKB/TrEMBL
    G5E8R3
    Related
    ENSMUSP00000153479.2, ENSMUST00000224726.3
    Conserved Domains (1) summary
    PRK12999
    Location:331178
    PRK12999; pyruvate carboxylase; Reviewed