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Pcsk6 proprotein convertase subtilisin/kexin type 6 [ Mus musculus (house mouse) ]

Gene ID: 18553, updated on 25-Sep-2017
Official Symbol
Pcsk6provided by MGI
Official Full Name
proprotein convertase subtilisin/kexin type 6provided by MGI
Primary source
MGI:MGI:102897
See related
Ensembl:ENSMUSG00000030513 Vega:OTTMUSG00000042239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPC4; Pace4; C86343; b2b2830Clo
Expression
Ubiquitous expression in liver adult (RPKM 17.9), cerebellum adult (RPKM 13.1) and 26 other tissues See more
Orthologs
Location:
7 C; 7 35.36 cM
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (65862136..66050386)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (73007022..73195272)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810008I18 gene Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 20684 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene selenoprotein S

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
PubMed 
glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
nerve growth factor production ISO
Inferred from Sequence Orthology
more info
 
peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein processing ISO
Inferred from Sequence Orthology
more info
 
secretion by cell ISO
Inferred from Sequence Orthology
more info
 
zygotic determination of anterior/posterior axis, embryo IGI
Inferred from Genetic Interaction
more info
PubMed 
zygotic determination of anterior/posterior axis, embryo IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
proprotein convertase subtilisin/kexin type 6
Names
paired basic amino acid cleaving system 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291184.1NP_001278113.1  proprotein convertase subtilisin/kexin type 6 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC132595, AC148973, AC165968
    Consensus CDS
    CCDS71978.1
    UniProtKB/TrEMBL
    E9Q4D0
    Related
    ENSMUSP00000095992.4, OTTMUSP00000062053, ENSMUST00000098391.10, OTTMUST00000111030
    Conserved Domains (8) summary
    cd04059
    Location:150444
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:720766
    FU; Furin-like repeats
    cd00064
    Location:672724
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:186469
    Peptidase_S8; Subtilase family
    pfam01483
    Location:529619
    P_proprotein; Proprotein convertase P-domain
    pfam08686
    Location:919942
    PLAC; PLAC (protease and lacunin) domain
    pfam15913
    Location:728824
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam16470
    Location:65141
    S8_pro-domain; Peptidase S8 pro-domain
  2. NM_011048.1NP_035178.1  proprotein convertase subtilisin/kexin type 6 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132595, AC148973, AC165968
    Consensus CDS
    CCDS52267.1
    UniProtKB/TrEMBL
    F6XJP7
    Related
    ENSMUSP00000053742.5, OTTMUSP00000062052, ENSMUST00000055576.11, OTTMUST00000111029
    Conserved Domains (8) summary
    cd04059
    Location:150444
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:733779
    FU; Furin-like repeats
    cd00064
    Location:685737
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:186469
    Peptidase_S8; Subtilase family
    pfam01483
    Location:529619
    P_proprotein; Proprotein convertase P-domain
    pfam08686
    Location:932955
    PLAC; PLAC (protease and lacunin) domain
    pfam15913
    Location:741837
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam16470
    Location:65141
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    65862136..66050386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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