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Pcsk4 proprotein convertase subtilisin/kexin type 4 [ Mus musculus (house mouse) ]

Gene ID: 18551, updated on 1-Mar-2024

Summary

Official Symbol
Pcsk4provided by MGI
Official Full Name
proprotein convertase subtilisin/kexin type 4provided by MGI
Primary source
MGI:MGI:97514
See related
Ensembl:ENSMUSG00000020131 AllianceGenome:MGI:97514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PC4; NEC3; SPC5; NEC 3
Summary
Predicted to enable serine-type endopeptidase activity. Involved in fertilization and sperm capacitation. Acts upstream of or within acrosome reaction and binding activity of sperm to zona pellucida. Located in acrosomal membrane. Is expressed in early conceptus; epididymis; gonad; and neural retina. Orthologous to human PCSK4 (proprotein convertase subtilisin/kexin type 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 108.7), duodenum adult (RPKM 13.6) and 5 other tissues See more
Orthologs
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Genomic context

See Pcsk4 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80157117..80165583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80321283..80329748, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5154 Neighboring gene ribosomal protein S15 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene STARR-positive B cell enhancer ABC_E8347 Neighboring gene RIKEN cDNA 2310011J03 gene Neighboring gene STARR-positive B cell enhancer ABC_E5155 Neighboring gene STARR-positive B cell enhancer ABC_E366 Neighboring gene predicted gene, 51809 Neighboring gene receptor accessory protein 6 Neighboring gene ADAMTS-like 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC63195

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acrosome reaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fertilization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm capacitation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sperm capacitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm capacitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
proprotein convertase subtilisin/kexin type 4
Names
KEX2-like endoprotease 3
neuroendocrine convertase 3
prohormone convertase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008793.2NP_032819.1  proprotein convertase subtilisin/kexin type 4 precursor

    See identical proteins and their annotated locations for NP_032819.1

    Status: VALIDATED

    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS24018.1
    UniProtKB/Swiss-Prot
    P29121, Q62094
    Related
    ENSMUSP00000020340.9, ENSMUST00000020340.15
    Conserved Domains (4) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:146419
    Peptidase_S8; Subtilase family
    pfam01483
    Location:488553
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80157117..80165583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513364.5XP_006513427.1  proprotein convertase subtilisin/kexin type 4 isoform X7

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:512577
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  2. XM_006513361.5XP_006513424.1  proprotein convertase subtilisin/kexin type 4 isoform X4

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:512577
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  3. XM_006513362.5XP_006513425.1  proprotein convertase subtilisin/kexin type 4 isoform X5

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:512577
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  4. XM_006513365.5XP_006513428.1  proprotein convertase subtilisin/kexin type 4 isoform X10

    Conserved Domains (3) summary
    pfam01483
    Location:320385
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
    cl10459
    Location:115226
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
  5. XM_006513360.5XP_006513423.1  proprotein convertase subtilisin/kexin type 4 isoform X3

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:512577
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  6. XM_006513359.5XP_006513422.1  proprotein convertase subtilisin/kexin type 4 isoform X2

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:512577
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  7. XM_006513358.5XP_006513421.1  proprotein convertase subtilisin/kexin type 4 isoform X1

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:512577
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  8. XM_006513369.5XP_006513432.1  proprotein convertase subtilisin/kexin type 4 isoform X12

    Conserved Domains (2) summary
    pfam01483
    Location:228293
    P_proprotein; Proprotein convertase P-domain
    cl10459
    Location:70120
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
  9. XM_036155689.1XP_036011582.1  proprotein convertase subtilisin/kexin type 4 isoform X9

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:459524
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  10. XM_030244951.2XP_030100811.1  proprotein convertase subtilisin/kexin type 4 isoform X8

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:488553
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  11. XM_006513363.5XP_006513426.1  proprotein convertase subtilisin/kexin type 4 isoform X6

    Conserved Domains (3) summary
    cd04059
    Location:115404
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:459524
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain
  12. XM_006513368.3XP_006513431.1  proprotein convertase subtilisin/kexin type 4 isoform X11

    See identical proteins and their annotated locations for XP_006513431.1

    Conserved Domains (2) summary
    cd04059
    Location:115387
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam16470
    Location:34110
    S8_pro-domain; Peptidase S8 pro-domain

RNA

  1. XR_004936124.1 RNA Sequence

  2. XR_003948614.2 RNA Sequence

  3. XR_004936123.1 RNA Sequence

  4. XR_003948612.2 RNA Sequence

  5. XR_003948611.2 RNA Sequence

  6. XR_003948615.2 RNA Sequence

  7. XR_004936125.1 RNA Sequence

  8. XR_004936127.1 RNA Sequence

  9. XR_004936126.1 RNA Sequence

  10. XR_004936122.1 RNA Sequence

  11. XR_003948610.2 RNA Sequence

  12. XR_004936120.1 RNA Sequence

  13. XR_004936121.1 RNA Sequence

  14. XR_003948609.2 RNA Sequence

  15. XR_004936119.1 RNA Sequence

  16. XR_004936117.1 RNA Sequence

  17. XR_004936118.1 RNA Sequence

  18. XR_003948605.2 RNA Sequence

  19. XR_003948607.2 RNA Sequence

  20. XR_380374.3 RNA Sequence

  21. XR_380375.4 RNA Sequence

  22. XR_380371.4 RNA Sequence

  23. XR_380370.3 RNA Sequence

  24. XR_380372.3 RNA Sequence