Format

Send to:

Choose Destination

Pbx2 pre B cell leukemia homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 18515, updated on 1-Oct-2021

Summary

Official Symbol
Pbx2provided by MGI
Official Full Name
pre B cell leukemia homeobox 2provided by MGI
Primary source
MGI:MGI:1341793
See related
Ensembl:ENSMUSG00000034673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G17
Expression
Ubiquitous expression in CNS E11.5 (RPKM 34.0), limb E14.5 (RPKM 28.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pbx2 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34811233..34816374)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34592259..34597400)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34729416..34734286)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene notch 4 Neighboring gene G-protein signalling modulator 3 (AGS3-like, C. elegans) Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene ring finger protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-B-cell leukemia transcription factor 2
Names
homeobox protein PBX2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017463.3NP_059491.1  pre-B-cell leukemia transcription factor 2

    See identical proteins and their annotated locations for NP_059491.1

    Status: VALIDATED

    Source sequence(s)
    AK159623, CT009767
    Consensus CDS
    CCDS28648.1
    UniProtKB/Swiss-Prot
    O35984
    UniProtKB/TrEMBL
    Q4FJL3
    Related
    ENSMUSP00000040464.7, ENSMUST00000038149.13
    Conserved Domains (2) summary
    cd00086
    Location:245305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:50243
    PBC; PBC domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34811233..34816374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center