Format

Send to:

Choose Destination

DUSP7 dual specificity phosphatase 7 [ Homo sapiens (human) ]

Gene ID: 1849, updated on 1-Jun-2020

Summary

Official Symbol
DUSP7provided by HGNC
Official Full Name
dual specificity phosphatase 7provided by HGNC
Primary source
HGNC:HGNC:3073
See related
Ensembl:ENSG00000164086 MIM:602749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKPX; PYST2
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression
Ubiquitous expression in esophagus (RPKM 18.5), skin (RPKM 16.3) and 24 other tissues See more
Orthologs

Genomic context

See DUSP7 in Genome Data Viewer
Location:
3p21.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (52048919..52056571, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52082935..52090461, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC105377088 Neighboring gene long intergenic non-protein coding RNA 696 Neighboring gene POC1 centriolar protein A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586F2224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
inactivation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 7
Names
dual specificity protein phosphatase PYST2
NP_001938.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001947.4NP_001938.2  dual specificity protein phosphatase 7

    See identical proteins and their annotated locations for NP_001938.2

    Status: VALIDATED

    Source sequence(s)
    AC115284, AL110157, BC019107, CN429806, DN999200, X93921
    Consensus CDS
    CCDS33766.2
    UniProtKB/Swiss-Prot
    Q16829
    Related
    ENSP00000417183.1, ENST00000495880.2
    Conserved Domains (3) summary
    COG2453
    Location:229393
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:245382
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:55186
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    52048919..52056571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center