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Reg3b regenerating islet-derived 3 beta [ Mus musculus (house mouse) ]

Gene ID: 18489, updated on 27-Feb-2024

Summary

Official Symbol
Reg3bprovided by MGI
Official Full Name
regenerating islet-derived 3 betaprovided by MGI
Primary source
MGI:MGI:97478
See related
Ensembl:ENSMUSG00000071356 AllianceGenome:MGI:97478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIP; Pap; PAP1; REG-III
Summary
Predicted to enable several functions, including identical protein binding activity; oligosaccharide binding activity; and peptidoglycan binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Acts upstream of or within response to bacterium. Located in collagen-containing extracellular matrix. Is expressed in central nervous system; dorsal root ganglion; hypoglossal nerve; and intestine. Orthologous to several human genes including REG3A (regenerating family member 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward large intestine adult (RPKM 14173.7) See more
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Genomic context

See Reg3b in Genome Data Viewer
Location:
6 C3; 6 34.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (78347868..78350449)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (78370885..78373466)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 21045 Neighboring gene STARR-seq mESC enhancer starr_16382 Neighboring gene STARR-seq mESC enhancer starr_16383 Neighboring gene predicted pseudogene 5576 Neighboring gene STARR-seq mESC enhancer starr_16386 Neighboring gene STARR-seq mESC enhancer starr_16388 Neighboring gene regenerating islet-derived 3 delta Neighboring gene regenerating islet-derived 3 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regenerating islet-derived protein 3-beta
Names
REG-3-beta
RegIII (beta)
pancreatitis-associated protein 1
reg III-beta
regenerating islet-derived protein III-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011036.1NP_035166.1  regenerating islet-derived protein 3-beta precursor

    See identical proteins and their annotated locations for NP_035166.1

    Status: VALIDATED

    Source sequence(s)
    D63359
    Consensus CDS
    CCDS20253.1
    UniProtKB/Swiss-Prot
    P35230
    UniProtKB/TrEMBL
    A0A0N4SWI2
    Related
    ENSMUSP00000094667.4, ENSMUST00000096904.6
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    78347868..78350449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)