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Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 18475, updated on 5-Mar-2024

Summary

Official Symbol
Pafah1b2provided by MGI
Official Full Name
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2provided by MGI
Primary source
MGI:MGI:108415
See related
Ensembl:ENSMUSG00000003131 AllianceGenome:MGI:108415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pafahb; mus[b]; 2610005M20Rik
Summary
Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity; identical protein binding activity; and platelet-activating factor acetyltransferase activity. Involved in spermatogenesis. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 37.3), CNS E18 (RPKM 36.5) and 28 other tissues See more
Orthologs
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Genomic context

See Pafah1b2 in Genome Data Viewer
Location:
9; 9 A5.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45876609..45923988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45965311..46012690, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A830035O19 gene Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E8289 Neighboring gene STARR-seq mESC enhancer starr_24013 Neighboring gene STARR-seq mESC enhancer starr_24014 Neighboring gene predicted gene, 46110 Neighboring gene SIK family kinase 3 Neighboring gene STARR-seq mESC enhancer starr_24018 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45928283-45928392 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-activating factor acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables platelet-activating factor acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha2
Names
PAF acetylhydrolase 30 kDa subunit
PAF-AH 30 kDa subunit
PAF-AH alpha2
PAF-AH subunit beta
platelet-activating factor acetylhydrolase IB subunit beta
NP_001344167.1
NP_001344168.1
NP_001344169.1
NP_001344170.1
NP_001344172.1
NP_001344173.1
NP_001344174.1
NP_001344175.1
NP_032801.2
XP_030099983.1
XP_030099984.1
XP_036010577.1
XP_036010578.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357238.1NP_001344167.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC122273
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:21230
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  2. NM_001357239.1NP_001344168.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC122273
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:16225
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  3. NM_001357240.1NP_001344169.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC122273
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:11220
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  4. NM_001357241.1NP_001344170.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
    Source sequence(s)
    AC122273, BY293328, CA328016
    Consensus CDS
    CCDS23139.1
    UniProtKB/Swiss-Prot
    Q61206, Q6PKE6, Q7TNP3
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:8217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  5. NM_001357243.1NP_001344172.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
    Source sequence(s)
    AC122273, CA328016
    Consensus CDS
    CCDS23139.1
    UniProtKB/Swiss-Prot
    Q61206, Q6PKE6, Q7TNP3
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Related
    ENSMUSP00000151196.2, ENSMUST00000215060.2
    Conserved Domains (1) summary
    cd01820
    Location:8217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  6. NM_001357244.1NP_001344173.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
    Source sequence(s)
    AC122273
    Consensus CDS
    CCDS23139.1
    UniProtKB/Swiss-Prot
    Q61206, Q6PKE6, Q7TNP3
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:8217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  7. NM_001357245.1NP_001344174.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
    Source sequence(s)
    AC122273
    Consensus CDS
    CCDS23139.1
    UniProtKB/Swiss-Prot
    Q61206, Q6PKE6, Q7TNP3
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:8217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  8. NM_001357246.1NP_001344175.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC122273, BY242419
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:8178
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  9. NM_008775.3NP_032801.2  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

    See identical proteins and their annotated locations for NP_032801.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
    Source sequence(s)
    AC122273, BB856076, BC056211
    Consensus CDS
    CCDS23139.1
    UniProtKB/Swiss-Prot
    Q61206, Q6PKE6, Q7TNP3
    UniProtKB/TrEMBL
    A0A1L1SVK0
    Related
    ENSMUSP00000127851.2, ENSMUST00000172450.3
    Conserved Domains (1) summary
    cd01820
    Location:8217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45876609..45923988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154685.1XP_036010578.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:11220
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  2. XM_030244123.2XP_030099983.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:16225
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  3. XM_036154684.1XP_036010577.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:16225
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  4. XM_030244124.2XP_030099984.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SVK0
    Conserved Domains (1) summary
    cd01820
    Location:11220
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...