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Oxtr oxytocin receptor [ Mus musculus (house mouse) ]

Gene ID: 18430, updated on 11-Apr-2024

Summary

Official Symbol
Oxtrprovided by MGI
Official Full Name
oxytocin receptorprovided by MGI
Primary source
MGI:MGI:109147
See related
Ensembl:ENSMUSG00000049112 AllianceGenome:MGI:109147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OTR
Summary
Predicted to enable oxytocin receptor activity; peptide hormone binding activity; and vasopressin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of blood pressure. Predicted to be located in adherens junction; apical plasma membrane; and microvillus. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; integumental system; and small intestine. Orthologous to human OXTR (oxytocin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 71.9), mammary gland adult (RPKM 22.4) and 3 other tissues See more
Orthologs
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Genomic context

See Oxtr in Genome Data Viewer
Location:
6 E3; 6 52.27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (112450646..112467800, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (112473683..112491035, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53304 Neighboring gene STARR-seq mESC enhancer starr_17017 Neighboring gene predicted gene, 35649 Neighboring gene caveolin 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:112497386-112497539 Neighboring gene predicted gene, 35706 Neighboring gene ADP-ribosylation factor GTPase activating protein 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables oxytocin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxytocin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables vasopressin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in maternal behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in maternal process involved in parturition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of uterine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of systemic arterial blood pressure by vasopressin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to amphetamine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to anoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm ejaculation ISO
Inferred from Sequence Orthology
more info
 
involved_in suckling behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
oxytocin receptor
Names
OT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081147.3NP_001074616.1  oxytocin receptor isoform 1

    See identical proteins and their annotated locations for NP_001074616.1

    Status: VALIDATED

    Source sequence(s)
    AC153594
    Consensus CDS
    CCDS39588.1
    UniProtKB/Swiss-Prot
    F8VQ78, P97926
    UniProtKB/TrEMBL
    Q3UPP9
    Related
    ENSMUSP00000051132.7, ENSMUST00000053306.8
    Conserved Domains (1) summary
    cd15387
    Location:40339
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001410246.1NP_001397175.1  oxytocin receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153594
    UniProtKB/TrEMBL
    A0A0N4SVY6
    Related
    ENSMUSP00000145300.2, ENSMUST00000204027.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    112450646..112467800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165923.1XP_036021816.1  oxytocin receptor isoform X1

    UniProtKB/Swiss-Prot
    F8VQ78, P97926
    UniProtKB/TrEMBL
    Q3UPP9
    Conserved Domains (1) summary
    cd15387
    Location:40339
    7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors