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Slc22a18 solute carrier family 22 (organic cation transporter), member 18 [ Mus musculus (house mouse) ]

Gene ID: 18400, updated on 3-Apr-2024

Summary

Official Symbol
Slc22a18provided by MGI
Official Full Name
solute carrier family 22 (organic cation transporter), member 18provided by MGI
Primary source
MGI:MGI:1336884
See related
Ensembl:ENSMUSG00000000154 AllianceGenome:MGI:1336884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HET; ITM; BWR1A; Impt1; TSSC5; Orctl2; BWSCR1A; Slc22a1l; p45-BWR1A
Summary
Predicted to enable transmembrane transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to act upstream of or within anion transport. Predicted to be located in apical plasma membrane; cytoplasm; and nuclear envelope. Predicted to be integral component of plasma membrane. Is expressed in several structures, including liver; metanephros; nervous system; placenta; and yolk sac. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 388.3), duodenum adult (RPKM 122.8) and 5 other tissues See more
Orthologs
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Genomic context

See Slc22a18 in Genome Data Viewer
Location:
7 F5; 7 88.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143027502..143053071)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143473726..143499334)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 1C Neighboring gene predicted gene, 33663 Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic anion transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
solute carrier family 22 member 18
Names
ORCTL-2
imprinted multi-membrane spanning polyspecific transporter-related protein 1
organic cationic transporter-like 2
tumor suppressing subtransferable candidate 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042760.2NP_001036225.1  solute carrier family 22 member 18 isoform b

    See identical proteins and their annotated locations for NP_001036225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon; hence, differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (b).
    Source sequence(s)
    AB012084, BU758157
    Consensus CDS
    CCDS22041.1
    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    UniProtKB/TrEMBL
    A0A0R4J0P7
    Related
    ENSMUSP00000101537.3, ENSMUST00000105917.3
    Conserved Domains (2) summary
    cd06174
    Location:14378
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:14367
    MFS_1; Major Facilitator Superfamily
  2. NM_001417039.1NP_001403968.1  solute carrier family 22 member 18 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC023248
  3. NM_001417040.1NP_001403969.1  solute carrier family 22 member 18 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC023248
  4. NM_001417041.1NP_001403970.1  solute carrier family 22 member 18 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC023248
  5. NM_008767.3NP_032793.2  solute carrier family 22 member 18 isoform b

    See identical proteins and their annotated locations for NP_032793.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (b).
    Source sequence(s)
    AK002460, BB869719, BE865039, BU758157
    Consensus CDS
    CCDS22041.1
    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    UniProtKB/TrEMBL
    A0A0R4J0P7
    Related
    ENSMUSP00000056082.6, ENSMUST00000052348.12
    Conserved Domains (2) summary
    cd06174
    Location:14378
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:14367
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143027502..143053071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508514.4XP_006508577.1  solute carrier family 22 member 18 isoform X4

    UniProtKB/TrEMBL
    Q05DG8
    Conserved Domains (1) summary
    cl28910
    Location:1271
    MFS; Major Facilitator Superfamily
  2. XM_006508513.3XP_006508576.1  solute carrier family 22 member 18 isoform X3

    UniProtKB/TrEMBL
    Q05DG8
    Conserved Domains (1) summary
    cl28910
    Location:1279
    MFS; Major Facilitator Superfamily
  3. XM_006508511.3XP_006508574.1  solute carrier family 22 member 18 isoform X1

    See identical proteins and their annotated locations for XP_006508574.1

    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    Conserved Domains (1) summary
    cd17331
    Location:13396
    MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters
  4. XM_006508512.3XP_006508575.1  solute carrier family 22 member 18 isoform X2

    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    Conserved Domains (1) summary
    cd17331
    Location:7366
    MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters