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Sigmar1 sigma non-opioid intracellular receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 18391, updated on 12-May-2024

Summary

Official Symbol
Sigmar1provided by MGI
Official Full Name
sigma non-opioid intracellular receptor 1provided by MGI
Primary source
MGI:MGI:1195268
See related
Ensembl:ENSMUSG00000036078 AllianceGenome:MGI:1195268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oprs1; Sig1R; sigma1R
Summary
This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in liver adult (RPKM 37.0), subcutaneous fat pad adult (RPKM 22.3) and 28 other tissues See more
Orthologs
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Genomic context

See Sigmar1 in Genome Data Viewer
Location:
4 A5; 4 22.05 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41738493..41741359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41738493..41741359, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dynactin 3 Neighboring gene AT-rich interaction domain 3C Neighboring gene STARR-positive B cell enhancer ABC_E2689 Neighboring gene predicted gene, 42274 Neighboring gene STARR-positive B cell enhancer ABC_E10231 Neighboring gene STARR-positive B cell enhancer ABC_E10232 Neighboring gene galactose-1-phosphate uridyl transferase Neighboring gene interleukin 11 receptor subunit alpha 1 Neighboring gene C-C motif chemokine ligand 27A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sigma non-opioid intracellular receptor 1
Names
opioid receptor, sigma 1
sigma 1 receptor variant SR-1D
sigma 1-type opioid receptor
sigma1-receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286538.1NP_001273467.1  sigma non-opioid intracellular receptor 1 isoform 2

    See identical proteins and their annotated locations for NP_001273467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' terminal exon which results in a frameshift compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF030198, AY390765, BB741155, BB851853
    UniProtKB/TrEMBL
    B7ZJH6
    Conserved Domains (1) summary
    pfam04622
    Location:13148
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
  2. NM_001286539.1NP_001273468.1  sigma non-opioid intracellular receptor 1 isoform 3

    See identical proteins and their annotated locations for NP_001273468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AF030198, AY390764, BB741155, BB851853
    Consensus CDS
    CCDS71362.1
    UniProtKB/TrEMBL
    A2AMS0
    Related
    ENSMUSP00000071492.7, ENSMUST00000071561.7
    Conserved Domains (1) summary
    pfam04622
    Location:13183
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
  3. NM_001286540.1NP_001273469.1  sigma non-opioid intracellular receptor 1 isoform 4

    See identical proteins and their annotated locations for NP_001273469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AF030198, AY390766, BB741155, BB851853
    UniProtKB/TrEMBL
    B7ZJH7
    Conserved Domains (1) summary
    pfam04622
    Location:13176
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
  4. NM_001286541.1NP_001273470.1  sigma non-opioid intracellular receptor 1 isoform 5

    See identical proteins and their annotated locations for NP_001273470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AF030198, AY390768, BB741155, BB851853
    UniProtKB/TrEMBL
    B7ZJH9
    Conserved Domains (1) summary
    pfam04622
    Location:51147
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
  5. NM_001286542.1NP_001273471.1  sigma non-opioid intracellular receptor 1 isoform 6

    See identical proteins and their annotated locations for NP_001273471.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The encoded protein (isoform 6) is shorter than isoform 1.
    Source sequence(s)
    AL807796
    UniProtKB/TrEMBL
    B7ZJH8
    Conserved Domains (1) summary
    pfam04622
    Location:36105
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
  6. NM_001286551.1NP_001273480.1  sigma non-opioid intracellular receptor 1 isoform 7

    See identical proteins and their annotated locations for NP_001273480.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. This isoform negatively regulates the function of the longest isoform (1) by forming a complex with the latter (PMID 22619170). Variants 7 and 8 encode the same protein.
    Source sequence(s)
    AF030198, BB741155, BB851853, BM507398
    UniProtKB/TrEMBL
    I4DCY6
    Conserved Domains (1) summary
    pfam04622
    Location:13102
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
  7. NM_001286605.1NP_001273534.1  sigma non-opioid intracellular receptor 1 isoform 7

    See identical proteins and their annotated locations for NP_001273534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. Variants 7 and 8 encode the same protein.
    Source sequence(s)
    AL807796
    UniProtKB/TrEMBL
    I4DCY6
    Conserved Domains (1) summary
    pfam04622
    Location:13102
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
  8. NM_011014.3NP_035144.1  sigma non-opioid intracellular receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_035144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF030198, BB741155, BB851853
    Consensus CDS
    CCDS18070.1
    UniProtKB/Swiss-Prot
    O55242, Q9JKU9
    Related
    ENSMUSP00000056027.8, ENSMUST00000059354.15
    Conserved Domains (1) summary
    pfam04622
    Location:13214
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41738493..41741359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)