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Sigmar1 sigma non-opioid intracellular receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 18391, updated on 2-Nov-2024

Summary

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Official Symbol
Sigmar1provided by MGI
Official Full Name
sigma non-opioid intracellular receptor 1provided by MGI
Primary source
MGI:MGI:1195268
See related
Ensembl:ENSMUSG00000036078 AllianceGenome:MGI:1195268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oprs1; Sig1R; sigma1R
Summary
This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in liver adult (RPKM 37.0), subcutaneous fat pad adult (RPKM 22.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sigmar1 in Genome Data Viewer
Location:
4 A5; 4 22.05 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41738493..41741359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41738493..41741359, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dynactin 3 Neighboring gene AT-rich interaction domain 3C Neighboring gene STARR-positive B cell enhancer ABC_E2689 Neighboring gene predicted gene, 42274 Neighboring gene STARR-positive B cell enhancer ABC_E10231 Neighboring gene STARR-positive B cell enhancer ABC_E10232 Neighboring gene galactose-1-phosphate uridyl transferase Neighboring gene interleukin 11 receptor subunit alpha 1 Neighboring gene C-C motif chemokine ligand 27A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor. Mavlyutov TA, et al. Mol Vis, 2011 Apr 26. PMID 21541278, Free PMC Article
  2. Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis. Shioda N, et al. J Biol Chem, 2012 Jul 6. PMID 22619170, Free PMC Article
  3. Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes. González LG, et al. Eur J Pharmacol, 2012 Feb 29. PMID 22227337
  4. Decreased brain sigma-1 receptor contributes to the relationship between heart failure and depression. Ito K, et al. Cardiovasc Res, 2012 Jan 1. PMID 21960687
  5. Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor. Kang DW, et al. Sci Rep, 2016 Dec 2. PMID 27910870, Free PMC Article

See all (188) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study.
    Title: Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study.
  2. Activation of the sigma-1 receptor ameliorates neuronal ferroptosis via IRE1alpha after spinal cord injury.
    Title: Activation of the sigma-1 receptor ameliorates neuronal ferroptosis via IRE1α after spinal cord injury.
  3. Genetic and Neuroimaging Analysis of SIGMAR1 for Frontotemporal Dementia.
    Title: Genetic and Neuroimaging Analysis of SIGMAR1 for Frontotemporal Dementia.
  4. Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury.
    Title: Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury.
  5. The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants.
    Title: The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants.
  6. Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.
    Title: Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.
  7. Pharmacological Analysis of GABAA Receptor and Sigma1R Chaperone Interaction: Research Report I-Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABAA Receptors' Ligands.
    Title: Pharmacological Analysis of GABA(A) Receptor and Sigma1R Chaperone Interaction: Research Report I-Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABA(A) Receptors' Ligands.
  8. Sigma 1 receptor activation improves retinal structure and function in the Rho[P23H/+] mouse model of autosomal dominant retinitis pigmentosa.
    Title: Sigma 1 receptor activation improves retinal structure and function in the Rho(P23H/+) mouse model of autosomal dominant retinitis pigmentosa.
  9. Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.
    Title: Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.
  10. Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.
    Title: Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.
Submit: New GeneRIF Correction See all GeneRIFs (112)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled opioid receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotrimerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynapse assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sigma non-opioid intracellular receptor 1
Names
opioid receptor, sigma 1
sigma 1 receptor variant SR-1D
sigma 1-type opioid receptor
sigma1-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286538.1 → NP_001273467.1  sigma non-opioid intracellular receptor 1 isoform 2

    See identical proteins and their annotated locations for NP_001273467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' terminal exon which results in a frameshift compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF030198, AY390765, BB741155, BB851853
    UniProtKB/TrEMBL
    B7ZJH6
    Conserved Domains (1) summary
    pfam04622
    Location:13 → 148
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

  2. NM_001286539.1 → NP_001273468.1  sigma non-opioid intracellular receptor 1 isoform 3

    See identical proteins and their annotated locations for NP_001273468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AF030198, AY390764, BB741155, BB851853
    Consensus CDS
    CCDS71362.1
    UniProtKB/TrEMBL
    A2AMS0
    Related
    ENSMUSP00000071492.7, ENSMUST00000071561.7
    Conserved Domains (1) summary
    pfam04622
    Location:13 → 183
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

  3. NM_001286540.1 → NP_001273469.1  sigma non-opioid intracellular receptor 1 isoform 4

    See identical proteins and their annotated locations for NP_001273469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AF030198, AY390766, BB741155, BB851853
    UniProtKB/TrEMBL
    B7ZJH7
    Conserved Domains (1) summary
    pfam04622
    Location:13 → 176
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

  4. NM_001286541.1 → NP_001273470.1  sigma non-opioid intracellular receptor 1 isoform 5

    See identical proteins and their annotated locations for NP_001273470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AF030198, AY390768, BB741155, BB851853
    UniProtKB/TrEMBL
    B7ZJH9
    Conserved Domains (1) summary
    pfam04622
    Location:51 → 147
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

  5. NM_001286542.1 → NP_001273471.1  sigma non-opioid intracellular receptor 1 isoform 6

    See identical proteins and their annotated locations for NP_001273471.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The encoded protein (isoform 6) is shorter than isoform 1.
    Source sequence(s)
    AL807796
    UniProtKB/TrEMBL
    B7ZJH8
    Conserved Domains (1) summary
    pfam04622
    Location:36 → 105
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

  6. NM_001286551.1 → NP_001273480.1  sigma non-opioid intracellular receptor 1 isoform 7

    See identical proteins and their annotated locations for NP_001273480.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. This isoform negatively regulates the function of the longest isoform (1) by forming a complex with the latter (PMID 22619170). Variants 7 and 8 encode the same protein.
    Source sequence(s)
    AF030198, BB741155, BB851853, BM507398
    UniProtKB/TrEMBL
    I4DCY6
    Conserved Domains (1) summary
    pfam04622
    Location:13 → 102
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

  7. NM_001286605.1 → NP_001273534.1  sigma non-opioid intracellular receptor 1 isoform 7

    See identical proteins and their annotated locations for NP_001273534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. Variants 7 and 8 encode the same protein.
    Source sequence(s)
    AL807796
    UniProtKB/TrEMBL
    I4DCY6
    Conserved Domains (1) summary
    pfam04622
    Location:13 → 102
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

  8. NM_011014.3 → NP_035144.1  sigma non-opioid intracellular receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_035144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF030198, BB741155, BB851853
    Consensus CDS
    CCDS18070.1
    UniProtKB/Swiss-Prot
    O55242, Q9JKU9
    Related
    ENSMUSP00000056027.8, ENSMUST00000059354.15
    Conserved Domains (1) summary
    pfam04622
    Location:13 → 214
    ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41738493..41741359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55242.1 GenPept UniProtKB/Swiss-Prot:O55242

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