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Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [ Mus musculus (house mouse) ]

Gene ID: 18383, updated on 23-Jul-2024

Summary

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Official Symbol
Tnfrsf11bprovided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)provided by MGI
Primary source
MGI:MGI:109587
See related
Ensembl:ENSMUSG00000063727 AllianceGenome:MGI:109587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Opg; TR1; OCIF
Summary
Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 3.7), liver E18 (RPKM 2.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfrsf11b in Genome Data Viewer
Location:
15 D1; 15 21.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54114014..54141700, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (54250619..54278484, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 12 Neighboring gene microRNA 28c Neighboring gene STARR-seq mESC enhancer starr_38685 Neighboring gene predicted gene 7489 Neighboring gene STARR-seq mESC enhancer starr_38686 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene predicted gene 5215

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Delayed denervation-induced muscle atrophy in Opg knockout mice. Zhang M, et al. Front Physiol, 2023. PMID 36909232, Free PMC Article
  2. Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice. Wu S, et al. Sci Rep, 2023 Feb 23. PMID 36823220, Free PMC Article
  3. Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin-Deficient Mice via Upregulation of Angiotensin (1-7). Karasaki K, et al. J Am Heart Assoc, 2023 Feb 7. PMID 36718875, Free PMC Article
  4. Genetic deletion of osteoprotegerin attenuates asthma development through suppression of inflammatory response in mice. Miyake T, et al. Cell Immunol, 2022 Aug. PMID 35691140
  5. Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice. Hamoudi D, et al. Hum Mol Genet, 2020 Feb 1. PMID 31943048

See all (204) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Osteoprotegerin Is Essential for the Development of Endothelial Dysfunction Induced by Angiotensin II in Mice.
    Title: Osteoprotegerin Is Essential for the Development of Endothelial Dysfunction Induced by Angiotensin II in Mice.
  2. Osteoprotegerin mediates adipogenesis in obesity.
    Title: Osteoprotegerin mediates adipogenesis in obesity.
  3. Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage.
    Title: Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage.
  4. Interleukin-13 reduces bone erosion in rheumatoid arthritis by up-regulating osteoprotegerin expression in fibroblast-like synoviocytes : an in vitro and in vivo study.
    Title: Interleukin-13 reduces bone erosion in rheumatoid arthritis by up-regulating osteoprotegerin expression in fibroblast-like synoviocytes : an in vitro and in vivo study.
  5. Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
    Title: Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
  6. Genetic deletion of osteoprotegerin attenuates asthma development through suppression of inflammatory response in mice.
    Title: Genetic deletion of osteoprotegerin attenuates asthma development through suppression of inflammatory response in mice.
  7. Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling.
    Title: Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling.
  8. LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1.
    Title: LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1.
  9. Incretins Enhance PGF2alpha-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts.
    Title: Incretins Enhance PGF2α-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts.
  10. Osteoprotegerin Expression in Liver is Induced by IL13 through TGFbeta.
    Title: Osteoprotegerin Expression in Liver is Induced by IL13 through TGFβ.
Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparan sulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 11B
Names
osteoclastogenesis inhibitory factor
osteoprotegerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411506.1 → NP_001398435.1  tumor necrosis factor receptor superfamily member 11B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121114
    UniProtKB/TrEMBL
    Q6PI12

  2. NM_008764.4 → NP_032790.3  tumor necrosis factor receptor superfamily member 11B isoform 1 precursor

    See identical proteins and their annotated locations for NP_032790.3

    Status: VALIDATED

    Source sequence(s)
    AC121114
    Consensus CDS
    CCDS27468.1
    UniProtKB/Swiss-Prot
    O08712, O70202
    UniProtKB/TrEMBL
    Q3UK97, Q6PI12
    Related
    ENSMUSP00000078705.4, ENSMUST00000079772.4
    Conserved Domains (3) summary
    cd00185
    Location:122 → 185
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    cd10581
    Location:7 → 151
    TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)
    pfam00531
    Location:293 → 365
    Death; Death domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    54114014..54141700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08712.1 GenPept UniProtKB/Swiss-Prot:O08712

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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