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Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [ Mus musculus (house mouse) ]

Gene ID: 18383, updated on 6-Jun-2024

Summary

Official Symbol
Tnfrsf11bprovided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)provided by MGI
Primary source
MGI:MGI:109587
See related
Ensembl:ENSMUSG00000063727 AllianceGenome:MGI:109587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Opg; TR1; OCIF
Summary
Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 3.7), liver E18 (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See Tnfrsf11b in Genome Data Viewer
Location:
15 D1; 15 21.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54114014..54141700, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (54250619..54278484, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 12 Neighboring gene microRNA 28c Neighboring gene STARR-seq mESC enhancer starr_38685 Neighboring gene predicted gene 7489 Neighboring gene STARR-seq mESC enhancer starr_38686 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene predicted gene 5215

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparan sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 11B
Names
osteoclastogenesis inhibitory factor
osteoprotegerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411506.1NP_001398435.1  tumor necrosis factor receptor superfamily member 11B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121114
    UniProtKB/TrEMBL
    Q6PI12
  2. NM_008764.4NP_032790.3  tumor necrosis factor receptor superfamily member 11B isoform 1 precursor

    See identical proteins and their annotated locations for NP_032790.3

    Status: VALIDATED

    Source sequence(s)
    AC121114
    Consensus CDS
    CCDS27468.1
    UniProtKB/Swiss-Prot
    O08712, O70202
    UniProtKB/TrEMBL
    Q3UK97, Q6PI12
    Related
    ENSMUSP00000078705.4, ENSMUST00000079772.4
    Conserved Domains (3) summary
    cd00185
    Location:122185
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    cd10581
    Location:7151
    TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)
    pfam00531
    Location:293365
    Death; Death domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    54114014..54141700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)