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Nthl1 nth (endonuclease III)-like 1 (E.coli) [ Mus musculus (house mouse) ]

Gene ID: 18207, updated on 1-Mar-2024

Summary

Official Symbol
Nthl1provided by MGI
Official Full Name
nth (endonuclease III)-like 1 (E.coli)provided by MGI
Primary source
MGI:MGI:1313275
See related
Ensembl:ENSMUSG00000041429 AllianceGenome:MGI:1313275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nth1; Octs3
Summary
Enables DNA N-glycosylase activity and DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in nucleotide-excision repair, DNA incision, 5'-to lesion. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 4.8), limb E14.5 (RPKM 4.3) and 28 other tissues See more
Orthologs
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Genomic context

See Nthl1 in Genome Data Viewer
Location:
17 A3.3; 17 12.42 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24851656..24857812)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24632680..24638838)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57643 Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene STARR-seq mESC enhancer starr_42089 Neighboring gene TSC complex subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E7498 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:24769632-24769741 Neighboring gene NHERF family PDZ scaffold protein 2 Neighboring gene neuropeptide W

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair TAS
Traceable Author Statement
more info
PubMed 
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
 
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in base-excision repair, AP site formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endonuclease III-like protein 1
Names
DNA glycoslyase/AP lyase
DNA glycosylase/AP lyase
bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase
bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase
thymine glycol DNA glycosylase/AP lyase
NP_001344544.1
NP_001411738.1
NP_032769.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357615.2NP_001344544.1  endonuclease III-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132367
    Related
    ENSMUST00000234635.2
    Conserved Domains (1) summary
    COG0177
    Location:28209
    Nth; Endonuclease III [Replication, recombination and repair]
  2. NM_001424809.1NP_001411738.1  endonuclease III-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132367
  3. NM_008743.2NP_032769.2  endonuclease III-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_032769.2

    Status: VALIDATED

    Source sequence(s)
    AC132367, AV377313, CJ211561, CX565655
    Consensus CDS
    CCDS28487.1
    UniProtKB/Swiss-Prot
    E9QMW1, O35980
    UniProtKB/TrEMBL
    B2RSG2
    Related
    ENSMUSP00000047413.3, ENSMUST00000047611.4
    Conserved Domains (1) summary
    COG0177
    Location:117298
    Nth; Endonuclease III [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24851656..24857812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)