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Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 [ Mus musculus (house mouse) ]

Gene ID: 18173, updated on 12-May-2024

Summary

Official Symbol
Slc11a1provided by MGI
Official Full Name
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1provided by MGI
Primary source
MGI:MGI:1345275
See related
Ensembl:ENSMUSG00000026177 AllianceGenome:MGI:1345275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcg; Ity; Lsh; ity; Ity1; Nramp; Nramp1
Summary
Enables manganese ion transmembrane transporter activity. Involved in metal ion export. Acts upstream of or within several processes, including cation homeostasis; defense response to other organism; and positive regulation of macromolecule metabolic process. Located in cytoplasmic vesicle and lysosome. Is expressed in several structures, including brain; gut; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 37.5), mammary gland adult (RPKM 13.7) and 19 other tissues See more
Orthologs
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Genomic context

See Slc11a1 in Genome Data Viewer
Location:
1 C3; 1 38.54 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74414318..74429974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74375014..74386057)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene paroxysmal nonkinesiogenic dyskinesia Neighboring gene STARR-positive B cell enhancer ABC_E3281 Neighboring gene STARR-positive B cell enhancer ABC_E4323 Neighboring gene STARR-seq mESC enhancer starr_01333 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:74433475-74433675 Neighboring gene ciliogenesis associated TTC17 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E2549 Neighboring gene STARR-seq mESC enhancer starr_01337 Neighboring gene predicted gene, 53562 Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene ubiquitin specific peptidase 37

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129156, MGC129157

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadmium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables iron ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables iron ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables iron ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables manganese ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables manganese ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal cation:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal cation:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal cation:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transition metal ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within L-arginine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within MHC class II biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell proliferation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cadmium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular detoxification of cadmium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-3 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in iron ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in iron ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iron ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in manganese ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within manganese ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in manganese ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in metal ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nitrite transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of dendritic cell antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within respiratory burst IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in phagocytic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in tertiary granule membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
natural resistance-associated macrophage protein 1
Names
NRAMP 1
host resistance locus Bcg/Ity/Lsh
solute carrier family 11 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013612.2NP_038640.2  natural resistance-associated macrophage protein 1

    See identical proteins and their annotated locations for NP_038640.2

    Status: VALIDATED

    Source sequence(s)
    AK171393, BB873183
    Consensus CDS
    CCDS15047.1
    UniProtKB/Swiss-Prot
    P41251, Q3TB84
    UniProtKB/TrEMBL
    A0A087WNR0
    Related
    ENSMUSP00000027368.6, ENSMUST00000027368.6
    Conserved Domains (1) summary
    TIGR01197
    Location:53453
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74414318..74429974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162734.1XP_036018627.1  natural resistance-associated macrophage protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P41251, Q3TB84
    UniProtKB/TrEMBL
    A0A087WNR0
    Conserved Domains (1) summary
    TIGR01197
    Location:53453
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
  2. XM_036162732.1XP_036018625.1  natural resistance-associated macrophage protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P41251, Q3TB84
    UniProtKB/TrEMBL
    A0A087WNR0
    Conserved Domains (1) summary
    TIGR01197
    Location:53453
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
  3. XM_036162735.1XP_036018628.1  natural resistance-associated macrophage protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P41251, Q3TB84
    UniProtKB/TrEMBL
    A0A087WNR0
    Conserved Domains (1) summary
    TIGR01197
    Location:53453
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
  4. XM_006495774.2XP_006495837.1  natural resistance-associated macrophage protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A087WNR0
    Conserved Domains (1) summary
    TIGR01197
    Location:1389
    nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters