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DRD5 dopamine receptor D5 [ Homo sapiens (human) ]

Gene ID: 1816, updated on 17-May-2020

Summary

Official Symbol
DRD5provided by HGNC
Official Full Name
dopamine receptor D5provided by HGNC
Primary source
HGNC:HGNC:3026
See related
Ensembl:ENSG00000169676 MIM:126453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBDR; DRD1B; DRD1L2
Summary
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See DRD5 in Genome Data Viewer
Location:
4p16.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (9781634..9784009)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (9783258..9785633)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene eva-1 homolog C (C. elegans) pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 35 pseudogene Neighboring gene solute carrier family 2 member 9 Neighboring gene RNA, 5S ribosomal pseudogene 154 Neighboring gene SLC2A9 antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Attention deficit hyperactivity disorder
MedGen: C1263846 OMIM: 143465 GeneReviews: Not available
Compare labs
Blepharospasm
MedGen: C4692845 OMIM: 606798 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-05-15)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-05-15)

ClinGen Genome Curation Page

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10601

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dopamine binding IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gs IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gs TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
associative learning IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to catecholamine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission NAS
Non-traceable Author Statement
more info
PubMed 
dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating dopamine receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of adenylate cyclase activity NAS
Non-traceable Author Statement
more info
PubMed 
reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by vasopressin IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
sensitization IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, dopaminergic NAS
Non-traceable Author Statement
more info
PubMed 
transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D(1B) dopamine receptor
Names
D1beta dopamine receptor
d(5) dopamine receptor
dopamine D5 receptor
dopamine receptor D1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012024.1 RefSeqGene

    Range
    5001..7376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000798.5NP_000789.1  D(1B) dopamine receptor

    See identical proteins and their annotated locations for NP_000789.1

    Status: REVIEWED

    Source sequence(s)
    AC098976, BC009748
    Consensus CDS
    CCDS3405.1
    UniProtKB/Swiss-Prot
    P21918
    Related
    ENSP00000306129.2, ENST00000304374.4
    Conserved Domains (2) summary
    pfam00001
    Location:57359
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:123175
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    9781634..9784009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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