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Npm1 nucleophosmin 1 [ Mus musculus (house mouse) ]

Gene ID: 18148, updated on 8-Jan-2023

Summary

Official Symbol
Npm1provided by MGI
Official Full Name
nucleophosmin 1provided by MGI
Primary source
MGI:MGI:106184
See related
Ensembl:ENSMUSG00000057113 AllianceGenome:MGI:106184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B23; Npm; NO38
Summary
Enables identical protein binding activity; protein N-terminus binding activity; and rRNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and protein stabilization. Acts upstream of or within several processes, including positive regulation of protein modification process; regulation of gene expression; and ribosome biogenesis. Located in centrosome; cytosol; and nuclear lumen. Part of large ribosomal subunit and small ribosomal subunit. Is expressed in several structures, including central nervous system; early conceptus; oocyte; and small intestine crypt of lieberkuhn. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 312.6), liver E14 (RPKM 236.0) and 16 other tissues See more
Orthologs
NEW
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Genomic context

See Npm1 in Genome Data Viewer
Location:
11; 11 A4
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (33102498..33114143, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (33152498..33164142, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4, pseudogene 4 Neighboring gene fibroblast growth factor 18 Neighboring gene Fgf18 promoter region Neighboring gene predicted gene 12115 Neighboring gene T cell leukemia, homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102162, MGC107291

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell volume homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell volume homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cellular biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cellular biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of centrosome duplication IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein destabilization IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein stabilization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within rRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within rRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of eIF2 alpha phosphorylation by dsRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA stability involved in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ribosomal large subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal small subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal small subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ribosomal small subunit export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in granular component IDA
Inferred from Direct Assay
more info
PubMed 
part_of large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleophosmin
Names
nucleolar phosphoprotein B23
nucleolar protein NO38
numatrin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252260.1NP_001239189.1  nucleophosmin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC089546, BU513690, CA540276, CX567338
    UniProtKB/TrEMBL
    Q5SQB7
    Conserved Domains (2) summary
    pfam03066
    Location:21106
    Nucleoplasmin; Nucleoplasmin
    pfam16276
    Location:230278
    NPM1-C; Nucleophosmin C-terminal domain
  2. NM_001252261.1NP_001239190.1  nucleophosmin isoform 3

    See identical proteins and their annotated locations for NP_001239190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons but has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC090843, CA540276
    Consensus CDS
    CCDS56765.1
    UniProtKB/TrEMBL
    A0A8C6HWT7, Q5BL09, Q9DAY9
    Related
    ENSMUSP00000104978.4, ENSMUST00000109354.10
    Conserved Domains (1) summary
    pfam03066
    Location:15119
    Nucleoplasmin; Nucleoplasmin
  3. NM_008722.3NP_032748.1  nucleophosmin isoform 1

    See identical proteins and their annotated locations for NP_032748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK165860, CA540276, CX567338
    Consensus CDS
    CCDS24532.1
    UniProtKB/Swiss-Prot
    Q61937
    UniProtKB/TrEMBL
    A0A6P5QKL1, A0A8C6HVT5, Q5SQB7
    Related
    ENSMUSP00000075067.4, ENSMUST00000075641.10
    Conserved Domains (2) summary
    pfam03066
    Location:18116
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    pfam16276
    Location:243291
    NPM1-C; Nucleophosmin C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    33102498..33114143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003949348.2 RNA Sequence