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DRD3 dopamine receptor D3 [ Homo sapiens (human) ]

Gene ID: 1814, updated on 3-Jun-2018
Official Symbol
DRD3provided by HGNC
Official Full Name
dopamine receptor D3provided by HGNC
Primary source
HGNC:HGNC:3024
See related
Ensembl:ENSG00000151577 MIM:126451; Vega:OTTHUMG00000159334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D3DR; ETM1; FET1
Summary
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
See DRD3 in Genome Data Viewer
Location:
3q13.31
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (114127623..114199407, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113847499..113918254, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2 Neighboring gene histone cluster 1, H2bj pseudogene Neighboring gene uncharacterized LOC107986115 Neighboring gene ZNF80-LTR promoter Neighboring gene family with sequence similarity 214 member B pseudogene Neighboring gene zinc finger protein 80

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Hereditary essential tremor 1
MedGen: C1860861 OMIM: 190300 GeneReviews: Not available
Compare labs
Schizophrenia
MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog
Genome-wide association study of the five-factor model of personality in young Korean women.
NHGRI GWA Catalog
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Dopamine receptors, organism-specific biosystem (from REACTOME)
    Dopamine receptors, organism-specific biosystemDopamine receptors play vital roles in processes such as the control of learning, motivation, fine motor control and modulation of neuroendocrine signaling (Giralt JA and Greengard P, 2004). Abnormal...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
    Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC149204, MGC149205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dopamine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dopamine binding IEA
Inferred from Electronic Annotation
more info
 
dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS
Inferred from Sequence or Structural Similarity
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
behavioral response to cocaine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
behavioral response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
behavioral response to cocaine ISS
Inferred from Sequence or Structural Similarity
more info
 
behavioral response to ethanol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
dopamine metabolic process IC
Inferred by Curator
more info
PubMed 
gastric emptying IEA
Inferred from Electronic Annotation
more info
 
learning NAS
Non-traceable Author Statement
more info
PubMed 
learning or memory NAS
Non-traceable Author Statement
more info
PubMed 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
musculoskeletal movement, spinal reflex action ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood volume by renin-angiotensin IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian sleep/wake cycle, sleep IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dopamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dopamine uptake involved in synaptic transmission IC
Inferred by Curator
more info
PubMed 
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT response to ethanol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to histamine IDA
Inferred from Direct Assay
more info
PubMed 
response to morphine ISS
Inferred from Sequence or Structural Similarity
more info
 
response to toxic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
social behavior NAS
Non-traceable Author Statement
more info
PubMed 
synaptic transmission, dopaminergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
D(3) dopamine receptor
Names
essential tremor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008842.2 RefSeqGene

    Range
    25356..75756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000796.5NP_000787.2  D(3) dopamine receptor isoform a

    See identical proteins and their annotated locations for NP_000787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the predominant transcript and encodes the longer isoform (a). Variants a, f and g encode the same isoform (a).
    Source sequence(s)
    AK292309, AY228458, BC095510
    Consensus CDS
    CCDS2978.1
    UniProtKB/Swiss-Prot
    P35462
    UniProtKB/TrEMBL
    A8K8E4, X5D2G4
    Related
    ENSP00000373169.2, ENST00000383673.4
    Conserved Domains (2) summary
    pfam00001
    Location:46383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44216
    7tm_4; Olfactory receptor
  2. NM_001282563.2NP_001269492.1  D(3) dopamine receptor isoform a

    See identical proteins and their annotated locations for NP_001269492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) differs in the 5' UTR compared to variant a. Variants a, f and g encode the same isoform (a).
    Source sequence(s)
    AK292309, BC095510
    Consensus CDS
    CCDS2978.1
    UniProtKB/Swiss-Prot
    P35462
    UniProtKB/TrEMBL
    A8K8E4, X5D2G4
    Related
    ENSP00000419402.1, OTTHUMP00000214909, ENST00000460779.5, OTTHUMT00000354699
    Conserved Domains (2) summary
    pfam00001
    Location:46383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44216
    7tm_4; Olfactory receptor
  3. NM_001290809.1NP_001277738.1  D(3) dopamine receptor isoform a

    See identical proteins and their annotated locations for NP_001277738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) has an additional internal exon in the 5' UTR, compared to variant a. Variants a, f and g encode the same isoform (a).
    Source sequence(s)
    AK292309, BC095510, BC128122
    Consensus CDS
    CCDS2978.1
    UniProtKB/Swiss-Prot
    P35462
    UniProtKB/TrEMBL
    A1A4V4, A8K8E4, X5D2G4
    Related
    ENSP00000420662.1, OTTHUMP00000214910, ENST00000467632.5, OTTHUMT00000354700
    Conserved Domains (2) summary
    pfam00001
    Location:46383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44216
    7tm_4; Olfactory receptor
  4. NM_033663.5NP_387512.3  D(3) dopamine receptor isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) has split coding exons at the 3' end compared to the penultimate coding exon of variant a. This results in a shorter isoform (e) missing a 33 aa segment compared to isoform a.
    Source sequence(s)
    AK292309, AY228458, BC095510, L20469
    Consensus CDS
    CCDS33829.1
    UniProtKB/Swiss-Prot
    P35462
    UniProtKB/TrEMBL
    A8K8E4, E9PCM4
    Related
    ENSP00000295881.6, ENST00000295881.9
    Conserved Domains (2) summary
    pfam00001
    Location:46350
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44216
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    114127623..114199407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005829.1XP_016861318.1  D(3) dopamine receptor isoform X1

    UniProtKB/TrEMBL
    X5D2G4
    Conserved Domains (2) summary
    pfam00001
    Location:46383
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:44216
    7tm_4; Olfactory receptor

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033658.1: Suppressed sequence

    Description
    NM_033658.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
  2. NM_033659.1: Suppressed sequence

    Description
    NM_033659.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_033660.1: Suppressed sequence

    Description
    NM_033660.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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