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Notch4 notch 4 [ Mus musculus (house mouse) ]

Gene ID: 18132, updated on 8-Feb-2024

Summary

Official Symbol
Notch4provided by MGI
Official Full Name
notch 4provided by MGI
Primary source
MGI:MGI:107471
See related
Ensembl:ENSMUSG00000015468 AllianceGenome:MGI:107471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N4; Int3; Int-3
Summary
Enables Notch binding activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of endothelial cell differentiation. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; positive regulation of angiogenesis; and positive regulation of aorta morphogenesis. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 37.2), adrenal adult (RPKM 14.3) and 14 other tissues See more
Orthologs
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Genomic context

See Notch4 in Genome Data Viewer
Location:
17 B1; 17 18.15 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34783257..34807517)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34564286..34588543)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene butyrophilin-like 6 Neighboring gene butyrophilin-like 7, pseudogene Neighboring gene predicted gene, 31560 Neighboring gene STARR-seq mESC enhancer starr_42434 Neighboring gene G-protein signalling modulator 3 (AGS3-like, C. elegans) Neighboring gene pre B cell leukemia homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in morphogenesis of a branching structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within venous blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neurogenic locus notch homolog protein 4
Names
Notch gene homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010929.2NP_035059.2  neurogenic locus notch homolog protein 4 precursor

    See identical proteins and their annotated locations for NP_035059.2

    Status: VALIDATED

    Source sequence(s)
    CT009767
    Consensus CDS
    CCDS28647.1
    UniProtKB/Swiss-Prot
    A2CG28, O35442, O88314, O88316, P31695, Q62389, Q62390, Q9R1W9, Q9R1X0
    UniProtKB/TrEMBL
    B2RQR1
    Related
    ENSMUSP00000015612.8, ENSMUST00000015612.14
    Conserved Domains (9) summary
    PTZ00322
    Location:17481828
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    smart00004
    Location:12031241
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:191229
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:429470
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:16291659
    ANK; ANK repeat [structural motif]
    pfam06816
    Location:12911337
    NOD; NOTCH protein
    pfam07684
    Location:13761415
    NODP; NOTCH protein
    pfam00066
    Location:12531281
    Notch; LNR domain
    pfam12796
    Location:16331726
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34783257..34807517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160366.1XP_036016259.1  neurogenic locus notch homolog protein 4 isoform X2

    Conserved Domains (6) summary
    smart00004
    Location:12071245
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:195233
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:433474
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00066
    Location:12551284
    Notch; LNR domain
    pfam06816
    Location:12951344
    NOD; NOTCH protein
    pfam07684
    Location:13791419
    NODP; NOTCH protein
  2. XM_006523798.4XP_006523861.1  neurogenic locus notch homolog protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006523861.1

    UniProtKB/TrEMBL
    B2RQR1
    Conserved Domains (7) summary
    smart00004
    Location:12071245
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:195233
    EGF_CA; Calcium-binding EGF-like domain
    COG0666
    Location:16441819
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:433474
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:16331663
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:12571285
    Notch; LNR domain
    pfam12796
    Location:16371730
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_004939477.1 RNA Sequence

    Related
    ENSMUST00000173389.8
  2. XR_385298.5 RNA Sequence