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Notch2 notch 2 [ Mus musculus (house mouse) ]

Gene ID: 18129, updated on 27-Feb-2024

Summary

Official Symbol
Notch2provided by MGI
Official Full Name
notch 2provided by MGI
Primary source
MGI:MGI:97364
See related
Ensembl:ENSMUSG00000027878 AllianceGenome:MGI:97364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N2
Summary
Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including heart looping; left/right axis specification; and marginal zone B cell differentiation. Acts upstream of or within several processes, including animal organ development; cholangiocyte proliferation; and positive regulation of BMP signaling pathway. Located in cilium and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 26.6), ovary adult (RPKM 22.8) and 28 other tissues See more
Orthologs
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Genomic context

See Notch2 in Genome Data Viewer
Location:
3 F2.2; 3 42.42 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97920854..98057683)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98013538..98150367)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4564 Neighboring gene SEC22 homolog B, vesicle trafficking protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97732943-97733126 Neighboring gene STARR-positive B cell enhancer ABC_E3452 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97737302-97737411 Neighboring gene VISTA enhancer mm576 Neighboring gene predicted gene 5544 Neighboring gene STARR-positive B cell enhancer ABC_E6087 Neighboring gene STARR-positive B cell enhancer ABC_E3453 Neighboring gene predicted gene, 40103 Neighboring gene STARR-seq mESC enhancer starr_08478 Neighboring gene STARR-positive B cell enhancer mm9_chr3:97961638-97961939 Neighboring gene a disintegrin and metallopeptidase domain 30 Neighboring gene RNA binding motif protein, X chromosome pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables NF-kappaB binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Notch signaling pathway IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bone remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell fate determination ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate determination TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholangiocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ciliary body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glomerular capillary formation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heart looping IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within humoral immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response to antigenic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within interleukin-4 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intrahepatic bile duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in left/right axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in marginal zone B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in podocyte development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in proximal tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of osteoclast development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
neurogenic locus notch homolog protein 2
Names
Motch B
Notch gene homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010928.2NP_035058.2  neurogenic locus notch homolog protein 2 precursor

    See identical proteins and their annotated locations for NP_035058.2

    Status: VALIDATED

    Source sequence(s)
    AC154173, AC164091, D32210
    Consensus CDS
    CCDS51013.1
    UniProtKB/Swiss-Prot
    G5E8J0, O35516, Q06008, Q60941
    Related
    ENSMUSP00000078741.7, ENSMUST00000079812.8
    Conserved Domains (10) summary
    smart00004
    Location:14591496
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:18802067
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:182218
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:19441975
    ANK; ANK repeat [structural motif]
    pfam06816
    Location:15401591
    NOD; NOTCH protein
    pfam07684
    Location:16211675
    NODP; NOTCH protein
    pfam11936
    Location:23852441
    DUF3454; Domain of unknown function (DUF3454)
    pfam15685
    Location:20702390
    GGN; Gametogenetin
    pfam00066
    Location:14231456
    Notch; LNR domain
    pfam12796
    Location:19492041
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    97920854..98057683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)