Nme1 NME/NM23 nucleoside diphosphate kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nme1provided by MGI
Official Full Name: NME/NM23 nucleoside diphosphate kinase 1provided by MGI
Primary source: MGI:MGI:97355
See related: Ensembl:ENSMUSG00000037601 AllianceGenome:MGI:97355
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GAAD; NDK1; NM23A; NDPK A; NDPK-A; NM23-M1
Summary: Predicted to enable several functions, including DNA binding activity; nuclease activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within lactation. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 107.7), CNS E18 (RPKM 93.1) and 28 other tissues See more
Orthologs: all
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Genomic context

Location:: 11 D; 11 58.89 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (93849751..93859341, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (93958925..93968272, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism.
Title: Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism.
Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.
Title: Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.
Histidine kinase NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis.
Title: Histidine kinase NME1 and NME2 are involved in TGF-β1-induced HSC activation and CCl(4)-induced liver fibrosis.
Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma.
Title: Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma.
these data indicate metastasis suppressor activity of NME1 in melanoma is mediated by induction of ITGB3 gene transcription.
Title: The metastasis suppressor NME1 inhibits melanoma cell motility via direct transcriptional induction of the integrin beta-3 gene.
Data identify NME1 as one of the two NME isoforms involved in class switch recombination (CSR) in B cells. Its knockdown leads to increased CSR. On the contrary of NME2, NME1 binds to S regions prior to stimulation.
Title: NME proteins regulate class switch recombination.
Deletion of NME1 reduced total NDPK activity and exacerbated activation of the stress-related MAPK, JNK, in the liver in response to paraquat. NDPK activity protects cells from acute oxidative stress by inhibiting activation of JNK in mammal models.
Title: Metastasis suppressor NM23 limits oxidative stress in mammals by preventing activation of stress-activated protein kinases/JNKs through its nucleoside diphosphate kinase activity.
EMMPRIN ensures proper actomyosin-driven maturation of competent endothelial junctions by forming a molecular complex with gamma-catenin (also known as junction plakoglobin) and Nm23 (also known as NME1), a nucleoside diphosphate kinase
Title: An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions.
data suggested that NME1 acts as a switcher or reprogramming factor which involves in oligodentrocyte versus neuron cell fate specification in vitro
Title: Nucleoside diphosphate kinase Nm23-M1 involves in oligodendroglial versus neuronal cell fate decision in vitro.
NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma.
Title: NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-DNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-DNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ADP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA nuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables coenzyme A binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables farnesyl diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables farnesyl diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables farnesyl diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intermediate filament binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphotransferase activity, phosphate group as acceptor	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, phosphate group as acceptor	ISO Inferred from Sequence Orthology more info
enables phosphotransferase activity, phosphate group as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables protein histidine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein histidine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein histidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal small subunit binding	IEA Inferred from Electronic Annotation more info
enables ribosomal small subunit binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables succinyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ITP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ITP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ITP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in acetyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	IEA Inferred from Electronic Annotation more info
involved_in apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
involved_in apoptotic DNA fragmentation	ISS Inferred from Sequence or Structural Similarity more info
involved_in dTMP biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in isoprenoid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myeloid leukocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in nucleoside diphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside diphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside triphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoside diphosphate kinase A

Names: NDK A; NDP kinase A; expressed in non-metastatic cells 1, protein; farnesyl diphosphate kinase NME1; histidine protein kinase NDK; metastasis inhibition factor NM23; non-metastatic cells 1, protein (NM23A) expressed in; non-specific serine/threonine protein kinase NME1; nucleoside diphoshate kinase 1; nucleoside-diphosphate kinase 1; nucleotide diphosphate kinase; putative 3'-5'-DNA exonuclease NDK1; putative granzyme A-activated DNA endonuclease; tumor metastatic process-associated protein

NP_001365783.1

EC 2.7.11.1

EC 2.7.13.3

EC 2.7.4.18

EC 2.7.4.6

NP_032730.1

EC 2.7.11.1

EC 2.7.13.3

EC 2.7.4.18

EC 2.7.4.6

XP_036012303.1

EC 2.7.11.1

EC 2.7.13.3

EC 2.7.4.18

EC 2.7.4.6

XP_036012304.1

EC 2.7.11.1

EC 2.7.13.3

EC 2.7.4.18

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378854.1 → NP_001365783.1 nucleoside diphosphate kinase A

Status: VALIDATED

Source sequence(s)

AL662838

UniProtKB/Swiss-Prot

P15532

UniProtKB/TrEMBL

Q5NC80, Q5NC81

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
NM_008704.3 → NP_032730.1 nucleoside diphosphate kinase A

See identical proteins and their annotated locations for NP_032730.1

Status: VALIDATED

Source sequence(s)

AL662838

Consensus CDS

CCDS25247.1

UniProtKB/Swiss-Prot

P15532

UniProtKB/TrEMBL

Q5NC80, Q5NC81

Related

ENSMUSP00000117022.2, ENSMUST00000135884.8

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

93849751..93859341 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156411.1 → XP_036012304.1 nucleoside diphosphate kinase A isoform X2

UniProtKB/TrEMBL

Q5NC79

Related

ENSMUSP00000103475.3, ENSMUST00000107844.3

Conserved Domains (1) summary

cl00335
Location:5 → 83

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
XM_036156410.1 → XP_036012303.1 nucleoside diphosphate kinase A isoform X1

Conserved Domains (1) summary

cl00335
Location:19 → 97

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...