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Nkx2-9 NK2 homeobox 9 [ Mus musculus (house mouse) ]

Gene ID: 18094, updated on 11-Apr-2024

Summary

Official Symbol
Nkx2-9provided by MGI
Official Full Name
NK2 homeobox 9provided by MGI
Primary source
MGI:MGI:1270158
See related
Ensembl:ENSMUSG00000058669 AllianceGenome:MGI:1270158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkx2-8; Nkx2.9; tinman; Nkx-2.9
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesoderm; liver; and lung epithelium. Orthologous to human NKX2-8 (NK2 homeobox 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 1.1), CNS E11.5 (RPKM 0.9) and 11 other tissues See more
Orthologs
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Genomic context

See Nkx2-9 in Genome Data Viewer
Location:
12 C1; 12 24.47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (56658174..56660354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (56611389..56613569, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32210 Neighboring gene predicted gene, 25760 Neighboring gene STARR-seq mESC enhancer starr_32211 Neighboring gene expressed sequence C87198 Neighboring gene STARR-seq mESC enhancer starr_32212 Neighboring gene STARR-seq mESC enhancer starr_32213 Neighboring gene predicted gene, 26973 Neighboring gene transcriptional adaptor 1 pseudogene Neighboring gene predicted gene 15524 Neighboring gene paired box 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein Nkx-2.8
Names
Drosophila NK2 transcription factor related, locus 9
NK2 transcription factor related, locus 9
homeobox protein NK-2 homolog H
homeobox protein Nkx-2.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008701.2NP_032727.2  homeobox protein Nkx-2.8

    See identical proteins and their annotated locations for NP_032727.2

    Status: VALIDATED

    Source sequence(s)
    AC160393
    Consensus CDS
    CCDS25923.1
    UniProtKB/Swiss-Prot
    B2RWY9, O70584
    Related
    ENSMUSP00000072425.6, ENSMUST00000072631.6
    Conserved Domains (1) summary
    pfam00046
    Location:84138
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    56658174..56660354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515533.4XP_006515596.1  homeobox protein Nkx-2.8 isoform X1

    See identical proteins and their annotated locations for XP_006515596.1

    UniProtKB/Swiss-Prot
    B2RWY9, O70584
    Conserved Domains (1) summary
    pfam00046
    Location:84138
    Homeobox; Homeobox domain