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Nkx2-6 NK2 homeobox 6 [ Mus musculus (house mouse) ]

Gene ID: 18092, updated on 21-Apr-2024

Summary

Official Symbol
Nkx2-6provided by MGI
Official Full Name
NK2 homeobox 6provided by MGI
Primary source
MGI:MGI:97351
See related
Ensembl:ENSMUSG00000044186 AllianceGenome:MGI:97351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tix; Nkx2.6; tinman; Nkx-2.6
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; digestive tract development; and pharyngeal system development. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and thymus. Orthologous to human NKX2-6 (NK2 homeobox 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 35.0) See more
Orthologs
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Genomic context

Location:
14 D2; 14 36.01 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (69409251..69412989)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69171802..69175540)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41192 Neighboring gene stanniocalcin 1 Neighboring gene STARR-seq mESC enhancer starr_37052 Neighboring gene STARR-seq mESC enhancer starr_37053 Neighboring gene RIKEN cDNA 1700092C10 gene Neighboring gene ribosomal protein S2, pseudogene 5 Neighboring gene predicted gene, 31632 Neighboring gene NK3 homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in atrial cardiac muscle cell development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in digestive tract development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryonic heart tube development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hypothalamus development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pericardium development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in pharyngeal system development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within pharyngeal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tongue development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ventricular cardiac muscle cell development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein Nkx-2.6
Names
Drosophila NK2 transcription factor related, locus 6
NK2 transcription factor related, locus 6
homeobox protein NK-2 homolog F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360218.1NP_001347147.1  homeobox protein Nkx-2.6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK006401, AK007304, CT025562
    UniProtKB/TrEMBL
    Q8CF35, Q9CVN3
    Conserved Domains (1) summary
    pfam00046
    Location:2982
    Homeobox; Homeobox domain
  2. NM_010920.2NP_035050.2  homeobox protein Nkx-2.6 isoform 1

    See identical proteins and their annotated locations for NP_035050.2

    Status: VALIDATED

    Source sequence(s)
    BC132558, CT025562
    Consensus CDS
    CCDS56968.1
    UniProtKB/Swiss-Prot
    P43688
    Related
    ENSMUSP00000049898.9, ENSMUST00000062437.10
    Conserved Domains (1) summary
    pfam00046
    Location:126179
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    69409251..69412989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)