Format

Send to:

Choose Destination

DPYSL3 dihydropyrimidinase like 3 [ Homo sapiens (human) ]

Gene ID: 1809, updated on 12-Aug-2018

Summary

Official Symbol
DPYSL3provided by HGNC
Official Full Name
dihydropyrimidinase like 3provided by HGNC
Primary source
HGNC:HGNC:3015
See related
Ensembl:ENSG00000113657 MIM:601168; Vega:OTTHUMG00000163437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1
Expression
Broad expression in brain (RPKM 51.8), prostate (RPKM 49.3) and 22 other tissues See more
Orthologs

Genomic context

See DPYSL3 in Genome Data Viewer
Location:
5q32
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (147390808..147510056, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (146770371..146889619, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene STK32A antisense RNA 1 Neighboring gene serine/threonine kinase 32A Neighboring gene JAKMIP2 antisense RNA 1 Neighboring gene uncharacterized LOC101927012 Neighboring gene janus kinase and microtubule interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
    CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
filamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin crosslink formation ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with exocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
filamentous actin ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 3
Names
collapsin response mediator protein 4 long
testicular secretory protein Li 7
unc-33-like phosphoprotein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197294.1NP_001184223.1  dihydropyrimidinase-related protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001184223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC077077, CA424493, D78014
    Consensus CDS
    CCDS56387.1
    UniProtKB/Swiss-Prot
    Q14195
    UniProtKB/TrEMBL
    A0A140VK07, Q6DEN2
    Related
    ENSP00000343690.5, OTTHUMP00000223927, ENST00000343218.9, OTTHUMT00000373423
    Conserved Domains (2) summary
    TIGR02033
    Location:131585
    D-hydantoinase; D-hydantoinase
    cl14632
    Location:574679
    VOC; vicinal oxygen chelate (VOC) family
  2. NM_001387.2NP_001378.1  dihydropyrimidinase-related protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform (1).
    Source sequence(s)
    AI570709, BC039006, CA424493, D78014
    Consensus CDS
    CCDS43381.1
    UniProtKB/Swiss-Prot
    Q14195
    UniProtKB/TrEMBL
    Q8IXW6
    Related
    ENSP00000381526.3, OTTHUMP00000223926, ENST00000398514.7, OTTHUMT00000373421
    Conserved Domains (2) summary
    TIGR02033
    Location:17471
    D-hydantoinase; D-hydantoinase
    cl14632
    Location:460565
    VOC; vicinal oxygen chelate (VOC) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    147390808..147510056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537574.2XP_011535876.1  dihydropyrimidinase-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011535876.1

    Conserved Domains (2) summary
    PRK09060
    Location:8463
    PRK09060; dihydroorotase; Validated
    TIGR02033
    Location:13467
    D-hydantoinase; D-hydantoinase
Support Center