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Nhlh2 nescient helix loop helix 2 [ Mus musculus (house mouse) ]

Gene ID: 18072, updated on 8-Feb-2024

Summary

Official Symbol
Nhlh2provided by MGI
Official Full Name
nescient helix loop helix 2provided by MGI
Primary source
MGI:MGI:97324
See related
Ensembl:ENSMUSG00000048540 AllianceGenome:MGI:97324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hen2; NSCL2; Nscl-2; bHLHa34; 6230401I09Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Acts upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Located in chromatin. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; head mesenchyme derived from neural crest; and sensory organ. Orthologous to human NHLH2 (nescient helix-loop-helix 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 15.9), whole brain E14.5 (RPKM 8.5) and 3 other tissues See more
Orthologs
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Genomic context

See Nhlh2 in Genome Data Viewer
Location:
3 F2.2; 3 44.3 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (101917425..101922808)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (102010111..102015492)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mab-21-like 3 Neighboring gene predicted gene, 33381 Neighboring gene solute carrier family 22 (organic anion/cation transporter), member 15 Neighboring gene STARR-seq mESC enhancer starr_08552 Neighboring gene STARR-seq mESC enhancer starr_08553 Neighboring gene STARR-seq mESC enhancer starr_08554 Neighboring gene STARR-seq mESC enhancer starr_08555 Neighboring gene STARR-seq mESC enhancer starr_08556 Neighboring gene STARR-seq mESC enhancer starr_08557 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08558 Neighboring gene calsequestrin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
helix-loop-helix protein 2
Names
HEN-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178777.3NP_848892.1  helix-loop-helix protein 2

    See identical proteins and their annotated locations for NP_848892.1

    Status: VALIDATED

    Source sequence(s)
    AC166072, AK031747
    Consensus CDS
    CCDS17685.1
    UniProtKB/Swiss-Prot
    Q64221, Q8BFV7
    Related
    ENSMUSP00000142746.2, ENSMUST00000196324.2
    Conserved Domains (1) summary
    cd19702
    Location:63135
    bHLH_TS_HEN2; basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    101917425..101922808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501112.4XP_006501175.1  helix-loop-helix protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006501175.1

    UniProtKB/Swiss-Prot
    Q64221, Q8BFV7
    Conserved Domains (1) summary
    cd19702
    Location:63135
    bHLH_TS_HEN2; basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar proteins