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Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [ Mus musculus (house mouse) ]

Gene ID: 18035, updated on 8-Feb-2024

Summary

Official Symbol
Nfkbiaprovided by MGI
Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alphaprovided by MGI
Primary source
MGI:MGI:104741
See related
Ensembl:ENSMUSG00000021025 AllianceGenome:MGI:104741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nfkbi
Summary
Predicted to enable several functions, including NF-kappaB binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; naris; and vibrissa follicle. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 93.5), spleen adult (RPKM 74.5) and 26 other tissues See more
Orthologs
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Genomic context

See Nfkbia in Genome Data Viewer
Location:
12 C1; 12 24.0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55536194..55539432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55489409..55492647, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571 Neighboring gene STARR-positive B cell enhancer ABC_E5329 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56547971-56548172 Neighboring gene STARR-positive B cell enhancer ABC_E11512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56566110-56566333 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56567450-56567696 Neighboring gene STARR-seq mESC enhancer starr_32186 Neighboring gene STARR-positive B cell enhancer ABC_E473 Neighboring gene STARR-positive B cell enhancer ABC_E7134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56600132-56600241 Neighboring gene STARR-seq mESC enhancer starr_32192 Neighboring gene predicted gene, 36634 Neighboring gene aldolase 1 A, retrogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to biotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoplasmic sequestering of NF-kappaB IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic sequestering of NF-kappaB ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription initiation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to muscle stretch IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NF-kappa-B inhibitor alpha
Names
I(Kappa)B(alpha)
I-kappa-B-alpha
I-kappaBalpha
ikB-alpha
ikappaBalpha
nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
nuclear factor of kappa light polyp gene enhancer in B-cell 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010907.2NP_035037.2  NF-kappa-B inhibitor alpha

    See identical proteins and their annotated locations for NP_035037.2

    Status: VALIDATED

    Source sequence(s)
    AC158398, AI462015, BC046754, CF379853
    Consensus CDS
    CCDS25918.1
    UniProtKB/Swiss-Prot
    Q3U9W9, Q3UB40, Q80ZX5, Q9Z1E3
    Related
    ENSMUSP00000021413.8, ENSMUST00000021413.9
    Conserved Domains (3) summary
    cd00204
    Location:105237
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:143180
    ANK; ANK repeat [structural motif]
    cl26073
    Location:26151
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55536194..55539432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)