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Nfil3 nuclear factor, interleukin 3, regulated [ Mus musculus (house mouse) ]

Gene ID: 18030, updated on 8-Feb-2024

Summary

Official Symbol
Nfil3provided by MGI
Official Full Name
nuclear factor, interleukin 3, regulatedprovided by MGI
Primary source
MGI:MGI:109495
See related
Ensembl:ENSMUSG00000056749 AllianceGenome:MGI:109495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E4BP4
Summary
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in large intestine adult (RPKM 2.7), CNS E14 (RPKM 2.5) and 28 other tissues See more
Orthologs
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Genomic context

See Nfil3 in Genome Data Viewer
Location:
13 B1; 13 27.68 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (53121245..53136914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (52967209..52982878, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33315 Neighboring gene AU RNA binding protein/enoyl-coenzyme A hydratase Neighboring gene STARR-seq mESC enhancer starr_34553 Neighboring gene STARR-positive B cell enhancer ABC_E3081 Neighboring gene STARR-positive B cell enhancer mm9_chr13:53024873-53025174 Neighboring gene STARR-seq mESC enhancer starr_34554 Neighboring gene STARR-positive B cell enhancer ABC_E4070 Neighboring gene predicted gene, 40950 Neighboring gene STARR-seq mESC enhancer starr_34555 Neighboring gene predicted gene, 33424 Neighboring gene predicted gene, 33519 Neighboring gene STARR-positive B cell enhancer mm9_chr13:53204966-53205267 Neighboring gene STARR-seq mESC enhancer starr_34558 Neighboring gene receptor tyrosine kinase-like orphan receptor 2 Neighboring gene predicted gene, 52058

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear factor interleukin-3-regulated protein
Names
E4 promoter-binding protein 4
embryo implantation-related NFIL3/E4BP4-like transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017373.3NP_059069.1  nuclear factor interleukin-3-regulated protein

    See identical proteins and their annotated locations for NP_059069.1

    Status: VALIDATED

    Source sequence(s)
    AK087541, BB872092, BC031377, BQ899715
    Consensus CDS
    CCDS26519.1
    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Related
    ENSMUSP00000065363.8, ENSMUST00000071065.8
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    53121245..53136914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516877.3XP_006516940.1  nuclear factor interleukin-3-regulated protein isoform X1

    See identical proteins and their annotated locations for XP_006516940.1

    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
  2. XM_036157903.1XP_036013796.1  nuclear factor interleukin-3-regulated protein isoform X1

    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
  3. XM_017315418.2XP_017170907.1  nuclear factor interleukin-3-regulated protein isoform X1

    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor