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Nfil3 nuclear factor, interleukin 3, regulated [ Mus musculus (house mouse) ]

Gene ID: 18030, updated on 19-Nov-2019

Summary

Official Symbol
Nfil3provided by MGI
Official Full Name
nuclear factor, interleukin 3, regulatedprovided by MGI
Primary source
MGI:MGI:109495
See related
Ensembl:ENSMUSG00000056749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E4BP4; AV225605
Summary
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in large intestine adult (RPKM 2.7), CNS E14 (RPKM 2.5) and 28 other tissues See more
Orthologs

Genomic context

See Nfil3 in Genome Data Viewer
Location:
13 B1; 13 27.68 cM
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (52967209..52982878, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (53062578..53076408, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33315 Neighboring gene AU RNA binding protein/enoyl-coenzyme A hydratase Neighboring gene predicted gene, 40950 Neighboring gene predicted gene, 33424 Neighboring gene predicted gene, 33519 Neighboring gene receptor tyrosine kinase-like orphan receptor 2 Neighboring gene predicted gene, 52058

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear factor interleukin-3-regulated protein
Names
E4 promoter-binding protein 4
embryo implantation-related NFIL3/E4BP4-like transcription factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017373.3NP_059069.1  nuclear factor interleukin-3-regulated protein

    See identical proteins and their annotated locations for NP_059069.1

    Status: VALIDATED

    Source sequence(s)
    AK087541, BB872092, BC031377, BQ899715
    Consensus CDS
    CCDS26519.1
    UniProtKB/Swiss-Prot
    O08750
    Related
    ENSMUSP00000065363.7, ENSMUST00000071065.7
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p6 C57BL/6J

    Range
    52967209..52982878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516877.3XP_006516940.1  nuclear factor interleukin-3-regulated protein isoform X1

    See identical proteins and their annotated locations for XP_006516940.1

    UniProtKB/Swiss-Prot
    O08750
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
  2. XM_011244379.1XP_011242681.1  nuclear factor interleukin-3-regulated protein isoform X1

    See identical proteins and their annotated locations for XP_011242681.1

    UniProtKB/Swiss-Prot
    O08750
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
  3. XM_017315418.1XP_017170907.1  nuclear factor interleukin-3-regulated protein isoform X1

    UniProtKB/Swiss-Prot
    O08750
    Conserved Domains (2) summary
    cd14694
    Location:72131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
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