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Nfe2l1 nuclear factor, erythroid derived 2,-like 1 [ Mus musculus (house mouse) ]

Gene ID: 18023, updated on 5-Mar-2024

Summary

Official Symbol
Nfe2l1provided by MGI
Official Full Name
nuclear factor, erythroid derived 2,-like 1provided by MGI
Primary source
MGI:MGI:99421
See related
Ensembl:ENSMUSG00000038615 AllianceGenome:MGI:99421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRF1; Lcrf1; TCF11; LCR-F1; TCF-11
Summary
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal adult (RPKM 102.3), heart adult (RPKM 69.1) and 28 other tissues See more
Orthologs
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Genomic context

See Nfe2l1 in Genome Data Viewer
Location:
11 D; 11 60.12 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96708239..96720810, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96817414..96829968, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1146 Neighboring gene sorting nexin 11 Neighboring gene STARR-seq mESC enhancer starr_30562 Neighboring gene chromobox 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30564 Neighboring gene STARR-seq mESC enhancer starr_30565 Neighboring gene STARR-positive B cell enhancer ABC_E9144 Neighboring gene STARR-positive B cell enhancer ABC_E9371 Neighboring gene STARR-positive B cell enhancer ABC_E201 Neighboring gene microRNA 152 Neighboring gene coatomer protein complex, subunit zeta 2 Neighboring gene STARR-positive B cell enhancer ABC_E2366 Neighboring gene predicted gene 11523 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (5) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cholesterol IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to cholesterol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to copper ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cysteine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fructose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glial cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitotic metaphase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of odontoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoplasmic reticulum membrane sensor NFE2L1
Names
NF-E2-related factor 1
NFE2-related factor 1
locus control region-factor 1
nuclear factor erythroid 2-related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130450.1NP_001123922.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

    See identical proteins and their annotated locations for NP_001123922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 5 encode the same isoform.
    Source sequence(s)
    AK038187, BC043063, CN527202
    Consensus CDS
    CCDS25304.1
    UniProtKB/Swiss-Prot
    E9Q038, O70234, Q61985
    UniProtKB/TrEMBL
    Q3U5L0, Q6GTN8
    Related
    ENSMUSP00000128527.2, ENSMUST00000167149.8
    Conserved Domains (1) summary
    cd14720
    Location:620687
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001130451.1NP_001123923.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

    See identical proteins and their annotated locations for NP_001123923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AK038187, CJ144781, CJ152359
    Consensus CDS
    CCDS48893.1
    UniProtKB/TrEMBL
    Q3V3M1
    Related
    ENSMUSP00000131585.2, ENSMUST00000169828.8
    Conserved Domains (1) summary
    cd14720
    Location:332399
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001130452.1NP_001123924.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

    See identical proteins and their annotated locations for NP_001123924.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AK038187, CJ152359
    Consensus CDS
    CCDS48893.1
    UniProtKB/TrEMBL
    Q3V3M1
    Conserved Domains (1) summary
    cd14720
    Location:332399
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  4. NM_001130453.1NP_001123925.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK038187, AK148471, CF163519
    Consensus CDS
    CCDS48894.1
    UniProtKB/TrEMBL
    Q3UFI8, Q3V3M1
    Related
    ENSMUSP00000127804.2, ENSMUST00000167110.8
    Conserved Domains (1) summary
    cd14720
    Location:462529
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  5. NM_001130454.1NP_001123926.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 4

    See identical proteins and their annotated locations for NP_001123926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK038187, AK148471
    UniProtKB/TrEMBL
    Q3UFI8
    Conserved Domains (1) summary
    cd14720
    Location:451518
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  6. NM_001361682.1NP_001348611.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK038187, AL596384, CF163519, CJ151652
    Conserved Domains (1) summary
    cd14720
    Location:493560
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  7. NM_008686.3NP_032712.2  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

    See identical proteins and their annotated locations for NP_032712.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 5 encode the same isoform.
    Source sequence(s)
    AK038187, AK152040, BC043063, BY301848
    Consensus CDS
    CCDS25304.1
    UniProtKB/Swiss-Prot
    E9Q038, O70234, Q61985
    UniProtKB/TrEMBL
    Q3U5L0, Q6GTN8
    Related
    ENSMUSP00000080467.6, ENSMUST00000081775.12
    Conserved Domains (1) summary
    cd14720
    Location:620687
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96708239..96720810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156406.1XP_036012299.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X4

    Conserved Domains (1) summary
    cd14720
    Location:324391
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  2. XM_036156405.1XP_036012298.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X3

    UniProtKB/TrEMBL
    Q3V3M1
    Conserved Domains (1) summary
    cd14720
    Location:332399
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  3. XM_036156403.1XP_036012296.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X1

    UniProtKB/TrEMBL
    Q3U5L0
    Conserved Domains (1) summary
    cd14720
    Location:567634
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  4. XM_036156404.1XP_036012297.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X2

    Conserved Domains (1) summary
    cd14720
    Location:440507
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain