Format

Send to:

Choose Destination

Nfe2l1 nuclear factor, erythroid derived 2,-like 1 [ Mus musculus (house mouse) ]

Gene ID: 18023, updated on 10-Oct-2019

Summary

Official Symbol
Nfe2l1provided by MGI
Official Full Name
nuclear factor, erythroid derived 2,-like 1provided by MGI
Primary source
MGI:MGI:99421
See related
Ensembl:ENSMUSG00000038615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRF1; Lcrf1; TCF11; LCR-F1; TCF-11; AA408798; AW212678
Summary
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal adult (RPKM 102.3), heart adult (RPKM 69.1) and 28 other tissues See more
Orthologs

Genomic context

See Nfe2l1 in Genome Data Viewer
Location:
11 D; 11 60.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96817414..96829968, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (96678728..96691282, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene sorting nexin 11 Neighboring gene chromobox 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene microRNA 152 Neighboring gene coatomer protein complex, subunit zeta 2 Neighboring gene predicted gene 11523 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cholesterol IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cholesterol IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
cysteine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fructose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
glucose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
mitotic metaphase IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of odontoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter in response to copper ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoplasmic reticulum membrane sensor NFE2L1
Names
NF-E2-related factor 1
NFE2-related factor 1
locus control region-factor 1
nuclear factor erythroid 2-related factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130450.1NP_001123922.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

    See identical proteins and their annotated locations for NP_001123922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 5 encode the same isoform.
    Source sequence(s)
    AK038187, BC043063, CN527202
    Consensus CDS
    CCDS25304.1
    UniProtKB/Swiss-Prot
    Q61985
    UniProtKB/TrEMBL
    Q3V3M1, Q6GTN8
    Related
    ENSMUSP00000128527.1, ENSMUST00000167149.7
    Conserved Domains (1) summary
    cd14720
    Location:620687
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001130451.1NP_001123923.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

    See identical proteins and their annotated locations for NP_001123923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AK038187, CJ144781, CJ152359
    Consensus CDS
    CCDS48893.1
    UniProtKB/TrEMBL
    Q3V3M1
    Related
    ENSMUSP00000131585.1, ENSMUST00000169828.7
    Conserved Domains (1) summary
    cd14720
    Location:332399
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001130452.1NP_001123924.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

    See identical proteins and their annotated locations for NP_001123924.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AK038187, CJ152359
    Consensus CDS
    CCDS48893.1
    UniProtKB/TrEMBL
    Q3V3M1
    Conserved Domains (1) summary
    cd14720
    Location:332399
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  4. NM_001130453.1NP_001123925.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK038187, AK148471, CF163519
    Consensus CDS
    CCDS48894.1
    UniProtKB/TrEMBL
    Q3UFI8, Q3V3M1
    Related
    ENSMUSP00000127804.1, ENSMUST00000167110.7
    Conserved Domains (1) summary
    cd14720
    Location:462529
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  5. NM_001130454.1NP_001123926.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 4

    See identical proteins and their annotated locations for NP_001123926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK038187, AK148471
    UniProtKB/TrEMBL
    Q3UFI8, Q3V3M1
    Conserved Domains (1) summary
    cd14720
    Location:451518
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  6. NM_001361682.1NP_001348611.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK038187, AL596384, CF163519, CJ151652
    Conserved Domains (1) summary
    cd14720
    Location:493560
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  7. NM_008686.3NP_032712.2  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

    See identical proteins and their annotated locations for NP_032712.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 5 encode the same isoform.
    Source sequence(s)
    AK038187, AK152040, BC043063, BY301848
    Consensus CDS
    CCDS25304.1
    UniProtKB/Swiss-Prot
    Q61985
    UniProtKB/TrEMBL
    Q3U5L0, Q3V3M1, Q6GTN8
    Related
    ENSMUSP00000080467.5, ENSMUST00000081775.11
    Conserved Domains (1) summary
    cd14720
    Location:620687
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    96817414..96829968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center