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Nfe2 nuclear factor, erythroid derived 2 [ Mus musculus (house mouse) ]

Gene ID: 18022, updated on 8-Feb-2024

Summary

Official Symbol
Nfe2provided by MGI
Official Full Name
nuclear factor, erythroid derived 2provided by MGI
Primary source
MGI:MGI:97308
See related
Ensembl:ENSMUSG00000058794 AllianceGenome:MGI:97308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p45; NF-E2; p45NFE2; p45nf-e2; NF-E2/P45
Summary
Predicted to enable several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Predicted to contribute to cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Located in nucleus. Is expressed in several structures, including dorsal aorta; eye; genitourinary system; limb; and yolk sac. Orthologous to human NFE2 (nuclear factor, erythroid 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 63.0), liver E14 (RPKM 51.5) and 2 other tissues See more
Orthologs
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Genomic context

See Nfe2 in Genome Data Viewer
Location:
15 F3; 15 58.62 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103156640..103166809, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103248212..103258403, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene chromobox 5 Neighboring gene STARR-seq mESC enhancer starr_39868 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 Neighboring gene STARR-seq mESC enhancer starr_39872 Neighboring gene STARR-positive B cell enhancer ABC_E81 Neighboring gene coatomer protein complex, subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene predicted gene, 41406

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of syncytium formation by plasma membrane fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of syncytium formation by plasma membrane fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of syncytium formation by plasma membrane fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of syncytium formation by plasma membrane fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor NF-E2 45 kDa subunit
Names
leucine zipper protein NF-E2
nuclear factor, erythroid derived 2, 45 kDa
nuclear factor, erythroid-derived 2 45 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302338.2NP_001289267.1  transcription factor NF-E2 45 kDa subunit

    See identical proteins and their annotated locations for NP_001289267.1

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS27900.1
    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Related
    ENSMUSP00000122476.2, ENSMUST00000149111.8
    Conserved Domains (1) summary
    cd14720
    Location:263330
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001302339.2NP_001289268.1  transcription factor NF-E2 45 kDa subunit

    See identical proteins and their annotated locations for NP_001289268.1

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS27900.1
    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Conserved Domains (1) summary
    cd14720
    Location:263330
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001302340.2NP_001289269.1  transcription factor NF-E2 45 kDa subunit

    See identical proteins and their annotated locations for NP_001289269.1

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS27900.1
    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Conserved Domains (1) summary
    cd14720
    Location:263330
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  4. NM_001302341.2NP_001289270.1  transcription factor NF-E2 45 kDa subunit

    See identical proteins and their annotated locations for NP_001289270.1

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS27900.1
    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Conserved Domains (1) summary
    cd14720
    Location:263330
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  5. NM_001302343.2NP_001289272.1  transcription factor NF-E2 45 kDa subunit

    See identical proteins and their annotated locations for NP_001289272.1

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS27900.1
    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Conserved Domains (1) summary
    cd14720
    Location:263330
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  6. NM_001400376.1NP_001387305.1  transcription factor NF-E2 45 kDa subunit

    Status: VALIDATED

    Source sequence(s)
    AC164069
    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Related
    ENSMUSP00000114160.2, ENSMUST00000156927.8
  7. NM_008685.4NP_032711.2  transcription factor NF-E2 45 kDa subunit

    See identical proteins and their annotated locations for NP_032711.2

    Status: VALIDATED

    Source sequence(s)
    AC164069
    Consensus CDS
    CCDS27900.1
    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Related
    ENSMUSP00000074684.7, ENSMUST00000075192.13
    Conserved Domains (1) summary
    cd14720
    Location:263330
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103156640..103166809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520573.4XP_006520636.1  transcription factor NF-E2 45 kDa subunit isoform X2

    See identical proteins and their annotated locations for XP_006520636.1

    UniProtKB/Swiss-Prot
    Q07279, Q6P6K5
    UniProtKB/TrEMBL
    A0A0R4J0Y5
    Conserved Domains (1) summary
    cd14720
    Location:263330
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain